Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...

β-Sitosterol Alleviates Neuropathic Pain by Inhibiting the TLR4/NF-κB Signaling Pathway Background Neuropathic pain is a common and difficult-to-treat chronic pain condition in clinical practice, with complex and not fully understood etiology. Research has shown that neuroinflammation is one of the main causes of chronic neuropathic pain. Microglia...

Research Background In recent years, Poly ADP-ribose Polymerase (PARP) inhibitors have shown significant efficacy as a key approach to treat hereditary BRCA1/2 mutation cancers. However, their effectiveness on tumors with other homologous recombination deficiency (HRD) gene mutations such as ATM, CDK12, and CHEK2 has been less satisfactory. Hence, ...

Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...

Research on Drug-Disease Association Prediction Using Graph Contrastive Learning Based on Layered Negative Sampling The prediction of drug-disease associations (RDAs) plays a critical role in unveiling disease treatment strategies and promoting drug repurposing. However, existing methods mainly rely on limited domain-specific knowledge when predict...

Research on Medical Package Recommendation Systems: Heterogeneous Graph Neural Network Based on Dual-Level Interaction Awareness With the widespread application of electronic health records (EHRs) in the medical field, how to mine potential and valuable medical knowledge to support clinical decision-making has become an important research direction...

From early drug discovery researchers face a daunting challenge – to find drug-like candidate molecules among approximately 10^60 possible molecular structures. One successful solution is to start from smaller “fragment” molecules, a strategy known as fragment-based drug design (FBDD). In the FBDD process, the first step is to computationally scree...