Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients Academic Background and Research Motivation During the treatment of active tuberculosis (Tuberculosis, TB), patients often experience tachycardia (Tachycardia), which typically diminishes as they recover. Elevated heart ...

Adiporon Ameliorates the Progression of Heart Failure with Preserved Ejection Fraction (HFpEF) by Reducing Lipid Accumulation and Fibrosis Research Background Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, often coexisting with metabolic disorders such as obesity, diabetes, and hypertension. Althoug...

Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway Background Vascular calcification is a pathological process involving the deposition of hydroxyapatite in the vessel wall, often associated with atherosclerotic cardiovascular disease and chronic kidney...

Single-Cell Transcriptomics Reveals the Relationship Between Cardiac Fibroblasts and Angiogenesis: The Key Role of ANGPTL4 in HFpEF Background Introduction Heart failure is one of the major global health challenges today. Heart failure is categorized into heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection...

Academic Background Pathological Myocardial Hypertrophy (PMH) is an adaptive response of the heart under various pathological stimuli, but its long-term development ultimately leads to Heart Failure (HF). Although some understanding of the pathogenesis of PMH has been established, its mortality rate remains high, and there is an urgent need for new...

Collecting Duct NCOR1 Regulates Blood Pressure by Controlling Mineralocorticoid Receptor Academic Background Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases globally, with complex and not fully elucidated mechanisms. The kidney plays a critical role in blood pressure regulation, particularly in the proc...

Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...

Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...