Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...

St. Jude Survivorship Portal: Analysis and Sharing of Large-Scale Clinical and Genomic Data of Pediatric Cancer Survivors Research Background In the United States, the five-year survival rate for childhood cancer has increased from about 60% in the 1970s to over 85% today. Despite the significant improvement in survival rates, these childhood cance...

Comprehensive Analysis of the Joint Impact of Polygenic Risk Scores and Lifestyle on Cardiovascular Disease Incidence: A Report from the China Kadoorie Biobank Introduction Cardiovascular disease (CVD) is one of the major global health threats. Despite the stable or declining incidence and prevalence of CVD among adults over 50 in recent decades, t...

Heart Failure Promotes Multimorbidity through Innate Immune Memory Background Introduction Heart failure (HF) is a common and fatal disease. Despite continuous advancements in medical technology, the mortality rate of heart failure remains high. HF patients frequently experience recurrent acute decompensation, which not only leads to the continuous...

Changes in Functional Brain Networks in Coronary Heart Disease Patients: Independent Component Analysis and Graph Theory Analysis This article, published in the 229th volume of “Brain Structure and Function” in 2024, explores the changes in functional connectivity (FC) and brain network topology in patients with coronary heart disease (CHD). The st...

CIGNN: A Framework for Cuffless Continuous Blood Pressure Estimation Based on Causality and Graph Neural Networks Background Introduction According to data from the World Health Organization (WHO), approximately 1.13 billion people globally are affected by hypertension, and this number is expected to increase to 1.5 billion by 2025. Hypertension is...

The Relationship between Treatment Speed of Endovascular Thrombectomy (EVT) for Acute Ischemic Stroke and Patient’s “Time at Home” Stroke is an acute disease with high disability and mortality rates. However, in recent years, the treatment efficacy of acute ischemic stroke has improved significantly with the development of endovascular thrombectomy...

Preventing Diabetic Cardiomyopathy through Suppressing TGR5-Mediated Fatty Acid Uptake Background and Problem Statement Diabetic Cardiomyopathy (DBCM) is a severe complication frequently faced by diabetic patients, characterized by lipid accumulation in the myocardium and cardiac dysfunction. Bile acid metabolism plays a crucial role in cardiovascu...

Characteristics, Quantity, and Spatial Distribution of Human Cervical Vagus Nerve and its Cardiac Superior Branch Nerve Fibers Introduction In modern medicine, Vagus Nerve Stimulation (VNS) is widely used to treat various diseases such as epilepsy, obesity, depression, and heart diseases. Although the overall Vagus nerve stimulation method has prov...

Heart Failure Promotes Multimorbidity through Innate Immune Memory Research Background Despite significant medical advances, the mortality rate of heart failure (HF) remains high, necessitating new therapeutic targets. HF patients often experience acute decompensation and develop comorbidities such as chronic kidney disease and frailty syndrome. Th...