Zinc-alpha2-glycoprotein Modulates Blood Pressure by Regulating Renal Lipid Metabolism Reprogramming-Mediated Urinary Na+ Excretion in Hypertension

Research Background Hypertension is one of the most common and serious health problems worldwide, with its high prevalence closely linked to an increased risk of cardiovascular diseases and stroke. Although the pathogenesis of hypertension is complex and involves multiple organs or systems (such as the kidneys, arteries, microcirculation, heart, an...

Smad1/5 is acetylated in the dorsal aortae of the mouse embryo driving early arterial gene expression

Academic Background During embryonic development, arteriovenous differentiation (AV differentiation) is a critical step in ensuring proper blood vessel formation and maturation. Defects in arterial or venous identity can lead to inappropriate fusion of vessels, resulting in so-called arteriovenous malformations (AVMs). Currently, the mechanism behi...

Circulating Dimethylguanidino Valeric Acid, Dietary Factors, and Risk of Coronary Heart Disease

Background Coronary Heart Disease (CHD) is one of the leading causes of death globally, with a complex pathogenesis involving multiple metabolic and dietary factors. In recent years, the development of metabolomics has provided new perspectives for studying CHD, particularly through the analysis of blood metabolites to uncover potential disease ris...

RNA Binding Protein with Multiple Splicing (RBPMS) Promotes Contractile Phenotype Splicing in Human Embryonic Stem Cell-Derived Vascular Smooth Muscle Cells

The Critical Role of RNA-Binding Protein RBPMS in Vascular Smooth Muscle Cells Academic Background Vascular Smooth Muscle Cells (VSMCs) are the primary structural components of large arteries. In healthy blood vessels, VSMCs exhibit a mature contractile phenotype, responsible for regulating vascular tone and blood flow. However, VSMCs possess pheno...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury in Critical Care

The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...

Imitation Learning for Path Planning in Cardiac Percutaneous Interventions

Application of Imitation Learning in Path Planning for Percutaneous Cardiac Interventions Academic Background Cardiac valve diseases, particularly mitral regurgitation (MR), are the third most common type of valvular heart disease globally and have a higher incidence in the elderly population. MR is characterized by the incomplete closure of the mi...

METTL14 Promotes Ferroptosis in Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4

Mettl14 Promotes Ferroptosis in Vascular Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4 Academic Background Thoracic aortic aneurysm (TAA) is a severe vascular disease that often leads to aortic rupture and acute dissection, with extremely high mortality rates. Currently, the primary treatment for T...

Bone Marrow-Derived NGFR-Positive Dendritic Cells Regulate Arterial Remodeling

Bone Marrow-Derived NGFR+ Dendritic Cells Regulate Arterial Remodeling Background Introduction Atherosclerosis is the primary pathological basis of cardiovascular disease, and its incidence continues to rise globally. Although extensive research has revealed the pathogenesis of atherosclerosis and led to the development of various therapeutic drugs...

The Runx2-NLRP3 Axis Orchestrates Matrix Stiffness-Evoked Vascular Smooth Muscle Cell Inflammation

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...