Delayed Inhibition of Plasma Kallikrein Promotes Stroke Recovery: By Reducing Thromboinflammation Academic Background Stroke is a common neurovascular event affecting over 60 million patients worldwide annually. Current treatments for cerebral ischemia are limited to thrombolysis and mechanical thrombectomy, which are constrained by the feasibility...
Breakthrough in Automated Echocardiogram Diagnosis via Deep Learning: A Comparative Study of Self-Supervised Learning Methods Research Background With the rapid development of artificial intelligence and machine learning technologies, their role in medical imaging diagnosis is becoming increasingly significant. In particular, Self-Supervised Learni...
In the global context, the prevalence of obesity is on the rise, bringing significant impacts to public health. Obesity is independently associated with the incidence and mortality of cardiovascular diseases, with an estimated economic burden exceeding $200 billion annually for healthcare systems. In recent years, glucagon-like peptide-1 (GLP-1) re...
Precision Imaging of Cardiac Function and Infarct Scar Size: A Study with Ultrahigh-Field MRI in Acute and Chronic Porcine Models of Myocardial Infarction Research Background Cardiac magnetic resonance imaging (MRI) is an accurate and highly reproducible technique for assessing cardiac function and volume. In recent years, ultrahigh-field (UHF) MRI...
Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...
St. Jude Survivorship Portal: Analysis and Sharing of Large-Scale Clinical and Genomic Data of Pediatric Cancer Survivors Research Background In the United States, the five-year survival rate for childhood cancer has increased from about 60% in the 1970s to over 85% today. Despite the significant improvement in survival rates, these childhood cance...
Comprehensive Analysis of the Joint Impact of Polygenic Risk Scores and Lifestyle on Cardiovascular Disease Incidence: A Report from the China Kadoorie Biobank Introduction Cardiovascular disease (CVD) is one of the major global health threats. Despite the stable or declining incidence and prevalence of CVD among adults over 50 in recent decades, t...
Heart Failure Promotes Multimorbidity through Innate Immune Memory Background Introduction Heart failure (HF) is a common and fatal disease. Despite continuous advancements in medical technology, the mortality rate of heart failure remains high. HF patients frequently experience recurrent acute decompensation, which not only leads to the continuous...
Changes in Functional Brain Networks in Coronary Heart Disease Patients: Independent Component Analysis and Graph Theory Analysis This article, published in the 229th volume of “Brain Structure and Function” in 2024, explores the changes in functional connectivity (FC) and brain network topology in patients with coronary heart disease (CHD). The st...
CIGNN: A Framework for Cuffless Continuous Blood Pressure Estimation Based on Causality and Graph Neural Networks Background Introduction According to data from the World Health Organization (WHO), approximately 1.13 billion people globally are affected by hypertension, and this number is expected to increase to 1.5 billion by 2025. Hypertension is...