Application of Imitation Learning in Path Planning for Percutaneous Cardiac Interventions Academic Background Cardiac valve diseases, particularly mitral regurgitation (MR), are the third most common type of valvular heart disease globally and have a higher incidence in the elderly population. MR is characterized by the incomplete closure of the mi...

Mettl14 Promotes Ferroptosis in Vascular Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4 Academic Background Thoracic aortic aneurysm (TAA) is a severe vascular disease that often leads to aortic rupture and acute dissection, with extremely high mortality rates. Currently, the primary treatment for T...

Bone Marrow-Derived NGFR+ Dendritic Cells Regulate Arterial Remodeling Background Introduction Atherosclerosis is the primary pathological basis of cardiovascular disease, and its incidence continues to rise globally. Although extensive research has revealed the pathogenesis of atherosclerosis and led to the development of various therapeutic drugs...

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...

Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients Academic Background and Research Motivation During the treatment of active tuberculosis (Tuberculosis, TB), patients often experience tachycardia (Tachycardia), which typically diminishes as they recover. Elevated heart ...

Adiporon Ameliorates the Progression of Heart Failure with Preserved Ejection Fraction (HFpEF) by Reducing Lipid Accumulation and Fibrosis Research Background Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, often coexisting with metabolic disorders such as obesity, diabetes, and hypertension. Althoug...

Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway Background Vascular calcification is a pathological process involving the deposition of hydroxyapatite in the vessel wall, often associated with atherosclerotic cardiovascular disease and chronic kidney...

Single-Cell Transcriptomics Reveals the Relationship Between Cardiac Fibroblasts and Angiogenesis: The Key Role of ANGPTL4 in HFpEF Background Introduction Heart failure is one of the major global health challenges today. Heart failure is categorized into heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection...

Academic Background Pathological Myocardial Hypertrophy (PMH) is an adaptive response of the heart under various pathological stimuli, but its long-term development ultimately leads to Heart Failure (HF). Although some understanding of the pathogenesis of PMH has been established, its mortality rate remains high, and there is an urgent need for new...

Collecting Duct NCOR1 Regulates Blood Pressure by Controlling Mineralocorticoid Receptor Academic Background Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases globally, with complex and not fully elucidated mechanisms. The kidney plays a critical role in blood pressure regulation, particularly in the proc...