Academic Background Preoperative anemia and red blood cell (RBC) transfusions are closely associated with poorer surgical outcomes. Although RBC transfusions can increase oxygen delivery, they are also linked to an increased risk of infectious complications, thromboembolic events, pneumonia, sepsis, cardiac events, and mortality. Therefore, when st...

Pulmonary Embolism (PE) Overview Pulmonary Embolism (PE) is a serious medical emergency with an annual incidence of approximately 60 to 120 cases per 100,000 people in North America and Europe. Most patients are diagnosed with PE in the Emergency Department (ED), and hospitalization is required for the majority of U.S. patients. Anticoagulation is ...

Association Between Cardiovascular Disease and Breast Cancer Stage at Diagnosis Academic Background Cardiovascular disease (CVD) and cancer are the two leading causes of mortality in the United States. Although they share many common risk factors, recent studies suggest that CVD may directly promote the occurrence and progression of cancer. Specifi...

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Potential Liver Roles Academic Background Fibrinogen is a crucial coagulation factor and acute-phase reactive protein. Under normal physiological conditions, fibrinogen is abundant in circulation, but during the acute inflammatory response, transcri...

Neuropilin-1 (Nrp1) is a multifunctional transmembrane protein that is abundantly expressed on the surface of various cell types, where it binds to class 3 semaphorins (Sema3), heparan sulfate, and vascular endothelial growth factors (VEGFs). Nrp1 plays a crucial role in angiogenesis and vascular permeability regulation, particularly in the VEGF si...

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues Academic Background The normal development and function of the vascular system rely on precise regulation of blood vessel diameter. Hemodynamic cues, such as fluid shear stress (FSS), are considered critical factors in regulating vessel diameter. According to...

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice Academic Background Aortic aneurysm (AA) is characterized by pathological dilation at specific predilection sites of the vessel, potentially leading to life-threatening vascular rupture. Aortic aneurysms typic...

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...

Global Surveillance of Circulating MicroRNA for Diagnostic and Prognostic Assessment of Acute Myocardial Infarction Based on Plasma Small RNA Sequencing Academic Background Acute Myocardial Infarction (AMI) is one of the most severe cardiovascular diseases leading to human mortality and morbidity worldwide. The pathological mechanism of AMI primari...

Report on the Study of Cardiac Dysfunction Among Breast Cancer Survivors Academic Background Breast cancer is the most common cancer diagnosed in women. Advances in early detection and novel therapeutics have yielded 5-year survival rates exceeding 90%. However, with over four million breast cancer survivors in the United States today, the quality ...