New Mechanism of Diabetic Cardiomyopathy: The Role of Fibroblast-Specific TGF-β/Smad3 Signaling Pathway Research Background Diabetes is a significant risk factor for cardiovascular diseases and heart failure (HF) globally. Diabetic patients not only face risks of macrovascular complications such as hypertension and atherosclerosis but are also pron...
Academic Background Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is a common cardiovascular disease, particularly among diabetic patients, whose incidence and mortality rates are significantly higher than those of non-diabetic patients. Although current clinical guidelines recommend early (within 24 hours) coronary revascularization ...
Background Folic Acid (FA) supplementation during pregnancy is widely recommended to reduce the risk of fetal congenital defects, particularly in the prevention of neural tube defects and congenital heart disease. However, despite the significant benefits of FA supplementation in preventing certain diseases, whether excessive FA supplementation may...
Academic Background Doxorubicin (Dox) is an anthracycline drug widely used in the treatment of tumors, but it exhibits dose-dependent cardiotoxicity, potentially leading to cardiomyopathy and heart failure. Despite its significant anticancer effects, the cardiotoxicity of Dox limits its clinical application. Currently, Dexrazoxane is the only FDA-a...
Research Background Hypertension is one of the most common and serious health problems worldwide, with its high prevalence closely linked to an increased risk of cardiovascular diseases and stroke. Although the pathogenesis of hypertension is complex and involves multiple organs or systems (such as the kidneys, arteries, microcirculation, heart, an...
Academic Background During embryonic development, arteriovenous differentiation (AV differentiation) is a critical step in ensuring proper blood vessel formation and maturation. Defects in arterial or venous identity can lead to inappropriate fusion of vessels, resulting in so-called arteriovenous malformations (AVMs). Currently, the mechanism behi...
Background Coronary Heart Disease (CHD) is one of the leading causes of death globally, with a complex pathogenesis involving multiple metabolic and dietary factors. In recent years, the development of metabolomics has provided new perspectives for studying CHD, particularly through the analysis of blood metabolites to uncover potential disease ris...
The Critical Role of RNA-Binding Protein RBPMS in Vascular Smooth Muscle Cells Academic Background Vascular Smooth Muscle Cells (VSMCs) are the primary structural components of large arteries. In healthy blood vessels, VSMCs exhibit a mature contractile phenotype, responsible for regulating vascular tone and blood flow. However, VSMCs possess pheno...
Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...
The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...