The Relationship Between Metabolic Reprogramming and Glutamine Metabolism in Glioblastoma Background Introduction Glioblastoma is a highly aggressive primary brain tumor with a very poor prognosis. Although current standard treatments include surgery, radiotherapy, and chemotherapy, there is no cure for the disease. In recent years, metabolic repro...

Inhibition of Liver Acetyl-CoA Carboxylase (ACC) Activity Exacerbates Liver Tumorigenesis in Mice Academic Background Liver cancer is the sixth most common cancer globally and the third leading cause of cancer-related mortality. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. In recent years, the burden of liver canc...

GCN2-SLC7A11 Axis Regulates Cell Growth and Survival in Retinoblastoma Under Arginine Deprivation Background Retinoblastoma (RB) is a common intraocular malignant tumor in children, accounting for 4% of all childhood cancers. Although current treatments such as chemotherapy are effective in some patients, they have drawbacks such as multidrug resis...

Transcriptome-Weighted Network Analysis of Glycosphingolipid Metabolism in Neuroblastoma Background Introduction Glycosphingolipids (GSLs) are a class of membrane lipids composed of a ceramide backbone linked to glycan moieties, widely present in the nervous system. They play crucial roles in cell signaling, cell-cell interactions, and tumorigenesi...

Real-Time Assessment of Mitochondrial ATP Synthesis Response: MitoRaise Academic Background Mitochondria are the energy factories within cells, primarily synthesizing adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). ATP serves as the main energy carrier in cells, and its synthesis rate directly reflects the functional status...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

RNF2 Promotes Chondrosarcoma Progression by Regulating Ubiquitination of CBX7 Academic Background Chondrosarcoma (CHS) is a malignant tumor composed of hyaline cartilage matrix and chondrocytes, ranking as the second most common primary bone tumor after osteosarcoma, accounting for 20%-27% of all primary malignant bone tumors. Although the 5-year s...

RhoF Promotes Snail1 Lactylation by Enhancing PKM2-Mediated Glycolysis to Induce Pancreatic Cancer Cell Endothelial–Mesenchymal Transition Academic Background Pancreatic cancer (PC) is a highly malignant tumor characterized by late diagnosis, strong invasiveness, and resistance to systemic therapy, leading to poor patient prognosis. Despite recent ...

Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy Academic Background Cancer is one of the leading causes of global mortality, significantly impacting patients’ quality of life. In recent years, photodynamic therapy (PDT) has garnered considerable attention as a promising technology for cancer...

Rapid and Large-Scale Synthesis of Chiral Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring Academic Background Fluorescent nanomaterials have broad application potential in fields such as energy harvesting, lighting displays, communication and information technology, biology, and medicine. Among them, sulfur quantum dots (SQ...