Neuronal AMPK Regulates Microglial Lipid Droplet Accumulation in Tauopathy Brain

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Neurons   AMPK   Lipid Droplets   Tauopathy   Microglia   Neuroinflammation   Lipid Metabolism  

Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...

The Browning and Mobilization of Subcutaneous White Adipose Tissue Supports Efficient Skin Repair

Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology,
White Adipose Tissue   Browning   Wound Healing   NRG4   Macrophage Polarization   Myofibroblast Function  

Browning of Subcutaneous White Adipose Tissue and Skin Repair Efficiency Current scientific research reveals that the participation of various cells is essential in the process of skin repair and regeneration. Among these, adipocytes (fat cells) have attracted attention due to their primary role in energy storage and critical endocrine functions in...

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
circadian rhythm   cancer metastasis   intestinal microbiota   myeloid-derived suppressor cells   tumor microenvironment  

Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...

White Matter Microstructural Changes Using Ultra-Strong Diffusion Gradient MRI in Adult-Onset Idiopathic Focal Cervical Dystonia

Medicine, Neurology, Medical Imaging,
white matter   microstructural   MRI   cervical dystonia   adult-onset   idiopathic focal  

Study Report on White Matter Microstructure Changes in Adult-Onset Idiopathic Focal Cervical Dystonia Patients Scientists are dedicated to studying Adult-Onset Idiopathic Focal Cervical Dystonia (AOIFCD), the most common type of idiopathic dystonia in adults. This condition primarily manifests as abnormal neck muscle postures, often accompanied by ...

Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients with Traumatic Brain Injury

Medicine, Emergency Medicine, Medical Laboratory Science, Neurology, Medical Imaging,
prehospital lactate levels   traumatic brain injury   in-hospital mortality   Glasgow Coma Scale   emergency care  

Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...

Long-term Dementia Risk in Parkinson Disease

Medicine, Geriatrics, Neurology, Life Sciences,
Parkinson's disease   dementia risk   long-term study   cognitive impairment   neurological disorders  

Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...

Clinical, Histopathologic, and Genetic Features of Patients with Myofibrillary and Distal Myopathies: Experience from the Italian Network

Medicine, Respiratory System, Neurology, Cardiovascular System, Life Sciences, Genetics,
Myofibrillary Myopathies   Distal Myopathies   Clinical Features   Histopathologic Features   Genetic Features   Italian Network   Molecular Confirmation  

Clinical, Histopathological, and Genetic Characterization: Insights from Myofibrillar and Distal Myopathies Patients in the Italian Network Background and Research Motivation Myofibrillar Myopathies (MFM) and Distal Myopathies (DM) are a group of rare diseases with complex pathological presentations. The diagnosis process is extremely complicated d...

Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency

Medicine, Pediatrics, Obstetrics and Gynecology, Neurology, Medical Imaging,
Pyruvate Dehydrogenase   Complex Deficiency   Fetal MRI   Brain Abnormalities   Genetic Disorder   Second Trimester Diagnosis  

Abnormalities in Fetal Brain MRI in Pyruvate Dehydrogenase Complex Deficiency Background and Research Objective Pyruvate Dehydrogenase Complex Deficiency (PDCD) is a mitochondrial metabolic disorder caused by pathogenic variants in multiple genes, including PDHA1. Classic neonatal brain imaging features have been described, mainly focusing on devel...

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients with Intracranial Hemorrhage and Mechanical Heart Valves

Medicine, Neurology, Neurosurgery, Hematology, Cardiovascular System,
Anticoagulation   Ischemic Complications   Hemorrhagic Complications   Mechanical Heart Valves   Intracranial Hemorrhage  

Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Sex Differences in the Risk of Stroke Associated with Traditional and Non-Traditional Factors in a US Cohort of People with HIV Infection

Medicine, Infectious Diseases, Neurology, Cardiovascular System,
HIV   stroke   sex differences   cardiovascular risk   lifestyle factors   HIV viremia  

Study on Gender Differences and Stroke Risk Among HIV-Infected Individuals Background Individuals with HIV infection may face a higher risk of stroke, particularly women. However, understanding of whether the influence of various factors on cerebrovascular risk in this population differs by gender and whether these differences contribute to variati...