Associations of Microbleeds and Their Topography with Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals with Down Syndrome

Medicine, Psychiatry, Geriatrics, Neurology, Medical Imaging,
Down Syndrome   Microbleeds   Alzheimer's Disease   Biomarkers   Imaging  

Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...

Clinicopathologic and Neuroimaging Correlations of Nonverbal Oral Apraxia in Patients with Neurodegenerative Disease

Medicine, Basic Medical Sciences, Neurology, Medical Imaging,
Nonverbal Oral Apraxia   Neurodegenerative Disease   Clinicopathologic   Neuroimaging   Progressive Supranuclear Palsy   Corticobasal Degeneration  

Nonverbal Oral Apraxia in Patients with Neurodegenerative Diseases: Clinical-Pathological and Neuroimaging Correlations Research Background Nonverbal Oral Apraxia (NVOA) is a condition characterized by the inability to plan, sequence, and execute voluntary oral-facial movements without muscle weakness. NVOA was first identified in stroke patients, ...

Genetic Associations with an Amyotrophic Lateral Sclerosis Reversal Phenotype

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Amyotrophic Lateral Sclerosis   Reversal Phenotype   Genome-Wide Association Study   Gene Expression   IGFBP7  

Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...

Effect of Immunosuppression in Risk of Developing Generalized Symptoms in Ocular Myasthenia Gravis

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
immunosuppression   ocular myasthenia gravis   generalization   steroids   retrospective study  

The Effect of Immunosuppression on the Risk of Generalization in Ocular Myasthenia Gravis Background Ocular Myasthenia Gravis (OMG) is an early and localized manifestation of Myasthenia Gravis (MG), with many patients initially presenting with ocular symptoms such as fatigable ptosis and diplopia. Approximately 85% of MG patients initially exhibit ...

Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011–2022

Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences,
Primary Progressive Aphasia   Primary Progressive Apraxia of Speech   Epidemiology   Prospective Study   Radiographic Characteristics  

Study on the Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County (2011-2022) Background and Study Objectives Primary Progressive Aphasia (PPA) and Primary Progressive Apraxia of Speech (PPAOS) are rare neurodegenerative diseases that respectively lead to the degeneration of language abilities and spe...

Sex-Specific Association of Cardiovascular Risk Factors with Migraine: The Population-Based Rotterdam Study

Medicine, Environmental and Public Health, Neurology, Cardiovascular System,
Cardiovascular Risk Factors   Migraine   Sex Differences   Population Study   Rotterdam Study   Middle-aged   Elderly  

Research Report on Gender-Specific Association Between Cardiovascular Risk Factors and Migraine Academic Background Migraine is a common neurological disorder. Previous studies have shown that migraine, especially migraine with aura, is associated with cardiovascular events such as myocardial infarction, coronary heart disease, and cardiovascular m...

Graded Multidimensional Clinical and Radiologic Variation in Patients with Alzheimer Disease and Posterior Cortical Atrophy

Medicine, Geriatrics, Neurology, Clinical Psychology, Medical Imaging,
Alzheimer Disease   Posterior Cortical Atrophy   Cognitive Impairments   Brain Volumes   Neuroimaging  

Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...

Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

Medicine, Environmental and Public Health, Neurology, Pharmacy,
pharmaceutical neuroenhancements   public views   regulation   societal effects   individual effects  

Research Report on Whether the Public Should Be Allowed to Use Drug Enhancers Introduction In recent years, some individuals have started using drugs to enhance cognitive and socio-emotional functions and have requested off-label prescriptions from doctors for neuroenhancement (e.g., stimulants). However, discussions about whether such uses should ...

Efficacy of Ofatumumab and Teriflunomide in Patients with Relapsing MS from Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses

Medicine, Rheumatology and Immunology, Neurology,
Ofatumumab   Teriflunomide   Relapsing Multiple Sclerosis   Racial/Ethnic Minority Groups   ASCLEPIOS Trials   No Evidence of Disease Activity  

Academic Paper Report Academic Background Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system characterized by the destruction of myelin and axons, leading to neurological dysfunction and progressive disability. It is estimated that there are approximately 2.8 million MS patients worldwide, with over 700,000 affected in...

Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Medicine, Geriatrics, Neurology, Cardiovascular System,
body composition   cardiovascular disease   neurodegenerative disease   UK Biobank   obesity  

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...