The Role of Oxyglutamate Carrier in Cerebral Ischemia-Reperfusion Injury Academic Background Cerebral ischemia-reperfusion injury (I/R) is a significant issue in the treatment of ischemic stroke. Although rapid blood flow restoration through thrombectomy and intravenous rt-PA (recombinant tissue plasminogen activator) administration can effectively...

Metabolic Characteristics of Pancreatic Ductal Adenocarcinoma (PDAC) Subtypes Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of only 13%, making it the third leading cause of cancer-related deaths. The aggressiveness and chemoresistance of PDAC are closely linked to its complex metabo...

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

PAF1/HIF1α Axis Promotes Pancreatic Cancer Aggressiveness by Regulating Glycolytic Metabolism Background Pancreatic cancer (PC) is a highly aggressive malignant tumor, with pancreatic ductal adenocarcinoma (PDAC) being the most common type. Despite significant advancements in cancer treatment in recent years, the 5-year survival rate for pancreatic...

The Role and Mechanism of STEAP3 in Cervical Cancer Background Cervical cancer (CC) is the fourth most common cancer among women globally, with approximately 600,000 new cases and 300,000 deaths annually. Although the five-year survival rate for early-stage cervical cancer patients exceeds 85% through treatments such as surgery, radiotherapy, and c...

Phosphatidylinositol Promotes Pituitary Adenoma Cell Proliferation and Invasion by Regulating POU1F1 Expression Background Pituitary adenoma (PA) is one of the most common primary intracranial tumors, accounting for approximately 15% of all intracranial tumors. Although most pituitary adenomas are benign, about 30% of them are invasive, known as in...

Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...

The Impact of a Whole Food, Plant-Based Diet on Amino Acid Levels in Patients with Metastatic Breast Cancer Research Background The growth and survival of cancer cells depend on significant metabolic demands, particularly for amino acids. Tumors meet these demands by acquiring amino acids from the surrounding microenvironment, and dietary amino aci...

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...

The Role of TDO2 Inhibition in Lung Cancer Immune Evasion Background Introduction Lung cancer is one of the leading causes of cancer-related deaths worldwide, with smoking recognized as a primary cause of its occurrence. Cigarette smoke contains numerous carcinogens, among which benzo[a]pyrene (BAP), a polycyclic aromatic hydrocarbon, has been show...