Clinical and Biological Heterogeneity in MYC/MYCN-Amplified Medulloblastoma Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Despite recent advances in treatment, approximately 30% of patients still die from the disease, and survivors often face long-term treatment-related complications. Amplifi...

Study on Relapse Patterns of Intracranial Ependymoma Background Ependymoma (EPn) is a rare but highly heterogeneous central nervous system tumor, particularly common in children. Despite significant advances in the biology and molecular characteristics of ependymoma in recent years, its relapse patterns remain unclear. The timing and location of re...

Diagnostic Accuracy and Value of 68Ga-Pentixafor PET/MRI in Tumor Localization for Cushing’s Disease Academic Background Cushing’s disease is the primary cause of Cushing’s syndrome, characterized by excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, often due to pituitary adenomas. Patients with chronic hypercortis...

Fabrication and In Vivo Testing of a Sub-mm Duckbill Valve for Hydrocephalus Treatment Academic Background Hydrocephalus is a complex pathological condition characterized by the accumulation of cerebrospinal fluid (CSF) in the cranium due to an imbalance between CSF production and absorption. This accumulation leads to increased intracranial pressu...

Long-term Clinical and Safety Outcomes from a Single-site Phase 1 Study of Neural Stem Cell Transplantation for Chronic Thoracic Spinal Cord Injury Academic Background Spinal cord injury (SCI) is a severe neurological condition that causes significant disability in millions of people worldwide. Traditional treatments primarily focus on stabilizing ...

Research Report: Reshaping Functional Hierarchies in Medication-Refractory Essential Tremor Through MRgFUS Therapy Essential tremor (ET), a prevalent movement disorder, is characterized by involuntary limb tremors, particularly noticeable during specific tasks. While traditional pharmacological treatments and deep brain stimulation (DBS) have shown...

Crossing the Blood–Brain Barrier: Study on Adipose-Derived Stem Cells as Carriers for Pro-Apoptotic Oncolytic Myxoma Virus in the Treatment of Murine Glioblastoma Background and Objective Glioblastoma (GBM) is among the most invasive and aggressive brain tumors, characterized by high recurrence rates and poor prognosis. Despite multimodal intervent...

Fibrotic Response Induced by Anti-CSF-1R Treatment Promotes Glioblastoma Recurrence Background Introduction Glioblastoma (GBM) is a highly aggressive and malignant primary tumor of the central nervous system. Although current standard treatments include surgical resection, Temozolomide chemotherapy, and fractionated radiotherapy, the median surviva...

Long-term Neuropsychological Trajectories in Pediatric Epilepsy Patients: Can Surgery Prevent Decline? Patients with long-term drug-resistant epilepsy (DRE) often face severe neuropsychological functional impairments, especially in children, which can significantly impact their academic performance, social relationships, and future employment oppor...

Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...