Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Study on the Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County (2011-2022) Background and Study Objectives Primary Progressive Aphasia (PPA) and Primary Progressive Apraxia of Speech (PPAOS) are rare neurodegenerative diseases that respectively lead to the degeneration of language abilities and spe...

The Role of p39 in Cerebral Ischemic Injury Background Introduction Stroke is an extremely serious public health problem, with current research mainly focusing on injury mechanisms and new target identification. p39, as an activator of CDK5 (Cyclin-dependent kinase 5), plays a crucial role in various diseases. This article mainly investigates the r...

Optogenetic Inhibition of Insular Cortex Glutamatergic Neurons Regulates Trigeminal Neuropathic Pain Introduction and Background Trigeminal neuropathic pain (TNP) is a severe facial disorder characterized by rapid and intense stabbing pain attacks that spread along the cutaneous segments of the trigeminal nerve. TNP occurs almost twice as frequentl...

Brain Glioblastoma PDGFRA, KIT and KDR Gene Amplification: Heterogeneity and Its Clinical Significance Academic Background Glioblastoma (GBM) is the most common malignant tumor of the central nervous system, with its heterogeneity posing significant challenges in treatment. GBM exhibits cellular genetic and phenotypic diversity not only between dif...

Correlation between Erf Gene Loss-of-Function Variants and Noonan Syndrome-like Phenotype - With or Without Craniosynostosis Research Background Members of the ETS transcription factor family play a crucial role in RAS-MAPK signal transduction, regulating the expression of “early response” genes and other functionally related genes. Among them, ETS...

New Gene Therapy Approach May Control Epileptic Seizures Caused by Focal Cortical Dysplasia Focal Cortical Dysplasia (FCD) is a type of disorder caused by abnormal cortical development, often accompanied by drug-resistant epilepsy and cognitive and behavioral disorders. According to the classification criteria proposed by Najm et al. in 2022 for th...

Study on MERTK Reducing Blood-Spinal Cord Barrier Permeability after Spinal Cord Injury via RhoA/ROCK1/p-MLC Pathway Spinal Cord Injury (SCI) is a central nervous system disease caused by trauma, inflammation, tumors, or other pathological reasons, resulting in sensory, motor, and autonomic nervous system dysfunction in patients, imposing a heavy b...

Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...

In the field of neuroscience, epilepsy has always been a disease of great concern, with significant challenges remaining in clinical research and treatment. Among these, the issue of secondary epileptogenesis has had a profound impact on academia and clinical treatment. Secondary epileptogenesis refers to the continuous spread of epileptic activity...