The Multifaceted Therapeutical Role of Low-Density Lipoprotein Receptor Family in High-Grade Glioma

Medicine, Neurology, Neurosurgery, Oncology,
Low-Density Lipoprotein Receptor   High-Grade Glioma   Targeted Therapies   Tumorigenesis   Signaling Pathways  

The Multifaceted Therapeutic Role of the Low-Density Lipoprotein Receptor Family in High-Grade Glioma Academic Background High-grade gliomas (HGG) are the most aggressive and prevalent primary brain tumors in the central nervous system (CNS), accounting for approximately 80% of all malignant brain tumors. Among them, glioblastoma (GBM) is the most ...

Relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats

Medicine, Neurology, Neurosurgery,
oxidative stress   neuronal apoptosis   relaxin-2   ERK-nNOS-NO pathway   germinal matrix hemorrhage   rat model   neuroprotection  

rh-relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats Academic Background Germinal Matrix Hemorrhage (GMH) is one of the most common neurological disorders in newborns, particularly in preterm infants, and is a major cause of brain injury. GMH not only triggers acute inf...

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus

Medicine, Psychiatry, Neurology, Neurosurgery, Clinical Psychology,
hydrocephalus   neuropsychology   cognition   research priorities   quality of life   clinical assessment   animal models  

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...

Phase-Contrast MRI Analysis of Cerebral Blood and CSF Flow Dynamic Interactions

Medicine, Neurology, Neurosurgery, Medical Imaging,
cerebral blood   CSF   volume change   intracranial   extracranial   flow dynamics   phase-contrast MRI  

Study on the Interaction Between Cerebral Blood Flow and Cerebrospinal Fluid Dynamics Measured at Intracranial and Extracranial Planes Background The interaction between cerebral blood flow (CBF) and cerebrospinal fluid (CSF) is a critical factor in maintaining intracranial pressure (ICP) stability. According to the Monro-Kellie doctrine, the intra...

ENPP1 Induces Blood–Brain Barrier Dysfunction and Promotes Brain Metastasis Formation in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Medicine, Neurology, Neurosurgery, Oncology,
blood-brain barrier   brain metastasis   HER2-positive breast cancer   ENPP1   insulin signaling pathway   endothelial cell dysfunction   prognostic biomarker  

The Role of ENPP1 in Brain Metastasis of HER2-Positive Breast Cancer Academic Background Brain metastasis (BM) is a severe neurological complication in patients with HER2-positive breast cancer (HER2+ BC), with an incidence rate as high as 50%. The formation of brain metastasis is closely related to how tumor cells cross the blood-brain barrier (BB...

Meningeal Solitary Fibrous Tumor Cell States Phenocopy Cerebral Vascular Development and Homeostasis

Medicine, Neurology, Neurosurgery, Oncology,
meningeal solitary fibrous tumor   single-cell RNA sequencing   spatial transcriptomics   cell-cell interactions   cerebral vascular development   tumor microenvironment   WHO histological grading  

Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...

Analysis of HER2 Expression Changes from Breast Primary to Brain Metastases and the Impact of HER2-Low Expression on Overall Survival

Medicine, Neurosurgery, Oncology,
breast cancer   brain metastases   HER2 expression   survival analysis   noninvasive diagnostics  

HER2 Expression Dynamics in Breast Cancer Brain Metastases and Its Impact on Survival Background Breast cancer is one of the most common cancers among women worldwide, and brain metastases (BrMs) pose a significant challenge for patients. In recent years, with the prolonged survival of breast cancer patients, the incidence of brain metastases has g...

Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors

Medicine, Neurology, Neurosurgery, Oncology,
glioma   molecular classification   survival rate   risk stratification   genomic diversity   prognostic features   molecular markers  

Molecular Classification and Prognostic Features of Gliomas Background Introduction Glioma is the most common malignant brain tumor in adults, and its classification, risk stratification, and treatment standards have undergone significant changes in recent years. With the introduction of molecular markers, the classification system for gliomas has ...

MYC-Dependent Upregulation of the De Novo Serine and Glycine Synthesis Pathway is a Targetable Metabolic Vulnerability in Group 3 Medulloblastoma

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   metabolic vulnerability   serine synthesis   glycine synthesis   PHGDH inhibition   therapeutic strategy  

Targeting the Serine/Glycine Synthesis Pathway in MYC-Driven Medulloblastoma Background Medulloblastoma is one of the most common malignant brain tumors in children, accounting for a significant proportion of childhood cancer deaths. Based on molecular characteristics, medulloblastoma is classified into four major subgroups: WNT, SHH, Group 3 (MBGr...

Long-term Outcome of the Milano-Hyperfractionated Accelerated Radiotherapy Strategy for High-Risk Medulloblastoma, Including the Impact of Molecular Subtype

Medicine, Neurology, Neurosurgery, Oncology,
high-risk medulloblastoma   hyperfractionated accelerated radiotherapy   molecular subtype   chemotherapy response   long-term survival  

Long-Term Outcomes of High-Risk Medulloblastoma Treatment Background Medulloblastoma is one of the most common malignant brain tumors in children. Despite advancements in treatment, the prognosis for high-risk medulloblastoma patients remains poor. High-risk medulloblastoma typically includes patients with metastatic disease, TP53 mutations, MYC/MY...