A novel protein cytb-187aa encoded by the mitochondrial gene cytb modulates mammalian early development

The New Protein Cytb-187aa Regulates Mammalian Early Development Academic Background Mitochondria are multifunctional organelles that provide energy for cells. In addition to energy supply, they are involved in the regulation of apoptosis, cell signaling, and various biosynthetic pathways. Among these functions, substances within mitochondria can b...

Oncogenic Fatty Acid Oxidation Senses Circadian Disruption in Sleep-Deficiency-Enhanced Tumorigenesis

Fatty Acid Oxidation in Lung Cancer Patients Induced by Sleep Loss Promotes Tumorigenesis Through Circadian Rhythm Disruption Background and Research Motivation Circadian rhythm regulation is one of the critical mechanisms for animals to maintain physiological homeostasis. However, disruptions in circadian rhythms have become a common phenomenon du...

Gut Microbial Alterations in Arginine Metabolism Determine Bone Mechanical Adaptation

The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....

Cytosolic pH is a Direct Nexus in Linking Environmental Cues with Insulin Processing and Secretion in Pancreatic β Cells

Cytosolic pH is a Direct Nexus in Linking Environmental Cues with Insulin Processing and Secretion in Pancreatic β Cells

The Direct Link between Cytosolic pH and Environmental Signals, Insulin Processing, and Secretion in Pancreatic β Cells Background Pancreatic β cells respond to glucose fluctuations by regulating insulin processing and secretion. However, how this process is finely tuned within a complex and variable microenvironment, and whether its dysfunction is...

Myocardial Infarction Accelerates the Progression of MASH by Triggering Immunoinflammatory Response and Induction of Periostin

Myocardial Infarction Accelerates the Progression of Metabolic Dysfunction-Associated Steatohepatitis by Inducing Immune Inflammatory Response and Periostin Background and Study Motivation Metabolic-associated steatohepatitis (MASLD, formerly NAFLD) is one of the most common chronic liver diseases worldwide, affecting about 25% of the adult populat...

Dietary Intake and Glutamine-Serine Metabolism Control Pathologic Vascular Stiffness

Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...

Imaging Brain Glucose Metabolism In Vivo Reveals Propionate as a Major Anaplerotic Substrate in Pyruvate Dehydrogenase Deficiency

Imaging Study of Brain Glucose Metabolism in Patients with Pyruvate Dehydrogenase Deficiency Background In modern mitochondrial medicine, evaluating the spectrum of brain diseases has been a limiting challenge. This limitation hinders our ability to understand the mechanisms behind the imaging phenotypes of the brains of mitochondrial disease patie...

A 5:2 Intermittent Fasting Regimen Ameliorates NASH and Fibrosis and Blunts HCC Development

New Scientific Discovery: The 5:2 Intermittent Fasting Regimen Improves Non-Alcoholic Steatohepatitis and Reduces Hepatocellular Carcinoma Occurrence Research Background and Problem Statement Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with its prevalence increasing alongside rising obesity rates. N...

Neuronal AMPK Regulates Microglial Lipid Droplet Accumulation in Tauopathy Brain

Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...

The Browning and Mobilization of Subcutaneous White Adipose Tissue Supports Efficient Skin Repair

Browning of Subcutaneous White Adipose Tissue and Skin Repair Efficiency Current scientific research reveals that the participation of various cells is essential in the process of skin repair and regeneration. Among these, adipocytes (fat cells) have attracted attention due to their primary role in energy storage and critical endocrine functions in...