Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...

Research Report on Potential Biomarkers for Early Detection of ADHD: Phase-Based Functional Brain Connectivity and Graph Theory Analysis This is a research report titled “Potential Biomarkers for Early Detection of ADHD: Using Phase-Based Functional Brain Connectivity and Graph Theory Analysis”. This study was conducted by Farhad Abedinzadeh Torgha...

Brain Science Research Inspires AI Algorithms: Neural Mechanisms of Knowledge Assembly Background Introduction When new information enters the brain, human pre-existing knowledge of the world can quickly change through a process called “knowledge assembly.” Recently, in a study conducted by Nelli et al., the neural correlates of knowledge assembly ...

Asthma Prediction Enhanced by Affinity Graph-Based Classifier: A Machine Learning Approach Using Routine Blood Biomarkers Background Asthma is a chronic respiratory disease that affects approximately 235 million people worldwide. According to the World Health Organization (WHO), the main characteristic of asthma is airway inflammation, leading to s...

The title of this paper is “Identification of Autism Spectrum Disorder Using Multiple Functional Connectivity-based Graph Convolutional Network,” published in the journal “Medical & Biological Engineering & Computing,” volume 62, pages 2133-2144, in 2024. This paper proposes a multiple functional connectivity-based graph convolutional network (mfc-...

Representation Learning of Lung Cancer Based on Graph Neural Networks Background Introduction With the rapid development of digital pathology, image-based diagnostic systems are becoming increasingly important in precise pathological diagnosis. These systems rely on Multiple Instance Learning (MIL) technology for Whole Slide Images (WSIs). However,...

Graph Theory Analysis of Brain Network Topology Structure in Patients with Primary Angle-Closure Glaucoma Research Background Glaucoma is a global blinding eye disease characterized by optic nerve damage and elevated intraocular pressure (IOP) (Kang and Tanna 2021). Among various types of glaucoma, Primary Angle-Closure Glaucoma (PACG) is particula...

Research Report on Changes in Functional Connectivity in Post-Stroke Epilepsy (PSE) Patients Based on Source-Level EEG and Graph Theory Research Background Epilepsy has various etiologies, including idiopathic, congenital, head trauma, central nervous system infections, brain tumors, neurodegenerative diseases, and cerebrovascular diseases. Among t...

Changes in Functional Brain Networks in Coronary Heart Disease Patients: Independent Component Analysis and Graph Theory Analysis This article, published in the 229th volume of “Brain Structure and Function” in 2024, explores the changes in functional connectivity (FC) and brain network topology in patients with coronary heart disease (CHD). The st...

Research on Drug-Disease Association Prediction Using Graph Contrastive Learning Based on Layered Negative Sampling The prediction of drug-disease associations (RDAs) plays a critical role in unveiling disease treatment strategies and promoting drug repurposing. However, existing methods mainly rely on limited domain-specific knowledge when predict...