The Ventral Subiculum Promotes Wakefulness Through Multiple Pathways in Male Mice Background The ventral subiculum (vsub) is a major output region of the hippocampus, playing a crucial role in motivation, stress integration, and anxiety-like behavior, all of which depend on a high state of wakefulness. However, the role of vsub in wakefulness and i...
Overview A paper titled “Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer’s disease progression” was published in Communications Biology. The paper was co-authored by research scientists from institutions such as McGill University, Université de Montréal, Yale University, and Rush Universi...
“Internal Speech Representation by Single Neurons in Human Supramarginal Gyrus” Scientific Report Background In recent years, Brain-Machine Interfaces (BMIs) technology has made significant advancements in the field of speech decoding. BMIs enable those who have lost the ability to speak due to disease or injury to communicate again by converting b...
Study of Neuroepithelial Genetic Markers and Prognosis in High-Grade Gliomas Background and Research Motivation High-grade gliomas are highly malignant brain tumors with generally poor patient prognosis. Previous preclinical model studies have suggested that interactions between neural and tumor cells drive tumor growth, but clinical validation of ...
Research Report: The Connection Between Cortical Gene Expression and Neurodevelopmental Disorders Research Background The anatomical and functional organization of the human brain is the result of the coordinated expression of numerous genes. It has been found that the first principal component (c1) of cortical gene expression plays a significant r...
Research Background Threat avoidance often comes at a cost, especially in situations involving threat-reward conflict, where avoiding threats might reduce the opportunity to gain potential rewards. In threat-reward conflicts, individuals need to balance the potential rewards and threat outcomes of their decisions to generate adaptive behavior. Howe...
Language and Sensory Characteristics of Very Low Birth Weight Children in Response to Sound Background and Motivation Very Low Birth Weight (VLBW) children face higher risks of cognitive developmental obstacles, including language deficits and sensory-motor difficulties. Previous studies have indicated that sound-evoked brain responses (P1m) can se...
Research on Gamma Oscillations Related to Suicidal Behavior in Patients with Depression Introduction Suicide is one of the most severe human behaviors globally, particularly prevalent among patients with Major Depressive Disorder (MDD). Studies have shown that nearly half of those who die by suicide had been diagnosed with MDD. Despite its signific...
Research Background and Objectives Empathy is the ability to understand and share the feelings of others and is a crucial foundation for human social interaction and prosocial behavior. Current neuroimaging studies have identified specific brain regions that play key roles in empathetic pain, including the anterior insula (AI), anterior cingulate c...
Evaluation of Epilepsy Seizure Onset Zone (SOZ) Implantation Quality through Spatial Perturbation Framework in Pre-Surgical Planning Background The success of epilepsy surgery relies heavily on the accuracy of pre-surgical planning, which typically involves identifying the epileptic zone (EZ) using clinical symptomatology, electroencephalography (E...