Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...

Identification of Nanaomycin A and Its Analogs as Functional Inhibitors of the Type IX Secretion System in Porphyromonas gingivalis Using a Novel Screening Method Academic Background Porphyromonas gingivalis is a Gram-negative anaerobic bacterium recognized as one of the primary pathogens in chronic periodontitis. Beyond periodontal diseases, P. gi...

Discovery and Research of the New Antibiotic Thiazoplanomicin Academic Background In recent years, the issue of antibiotic resistance has become increasingly severe, particularly with Neisseria gonorrhoeae (gonococcus), a common sexually transmitted pathogen. Gonococcus can rapidly develop drug resistance, rendering traditional antibiotics such as ...

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Structure-Activity Relationship Studies of ME1111—A Novel Antifungal Agent for Topical Treatment of Onychomycosis Background Onychomycosis is a globally prevalent disease affecting approximately 5.5% of the world’s population. Among its subtypes, distal-lateral subungual onychomycosis (DLSO) is the most common. The treatment of onychomycosis typica...

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

Staphylococcus Aureus Vesicles Impair Cutaneous Wound Healing Through p38 MAPK-MerTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis Background Introduction Staphylococcus aureus (S. aureus) is one of the primary pathogens causing chronic wound infections, particularly in diabetic patients, with an infection rate as high as 65%. One of the...

Report on a Study of the Dynamics of Carriage, Acquisition, and Transmission of ESBL-Producing E. coli (ESBL-EC) in Non-ICU Hospital Wards Over Two Years Antimicrobial resistance is an increasingly significant global public health issue, with the rapid dissemination of extended-spectrum beta-lactamase-producing (ESBL) Enterobacterales, such as Kleb...

Revisiting Mutational Resistance to Ampicillin and Cefotaxime in Haemophilus influenzae Background and Motivation for the Study Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract infections and invasive infections such as septicemia and meningitis, particularly in infants, the elderly, and immunoco...

Report on the Research Paper: Comprehensive Pathogen Identification and Antimicrobial Resistance Prediction from Positive Blood Cultures Using Nanopore Sequencing Technology Academic Context Bloodstream infections (BSIs) are severe clinical conditions typically diagnosed through positive blood culture results and systemic signs of infection. BSIs c...