Multi-modal Analysis Reveals Tumor and Immune Features Distinguishing EBV-Positive and EBV-Negative Post-Transplant Lymphoproliferative Disorders

Report on the Academic Paper: “Multi-modal Analysis Reveals Tumor and Immune Features Distinguishing EBV-positive and EBV-negative Post-transplant Lymphoproliferative Disorders” Summary The Epstein-Barr virus (EBV) is a widely disseminated gamma-1 herpesvirus that infects approximately 90%-95% of adults globally. While EBV infection is typically as...

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Neuroprotection with Glyceryl Trinitrate Post-Endovascular Therapy in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...

Targeting SNRNP200-Induced Splicing Dysregulation as an Immunotherapy Opportunity for Glycolytic Triple-Negative Breast Cancer

Targeting SNRNP200-Induced Splicing Dysregulation: A New Strategy for Immunotherapy in Glycolytic Triple-Negative Breast Cancer Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by extremely high recurrence and mortality rates. Despite significant recent advances in research on TNBC subty...

Bacterial Toxins Induce Non-Canonical Migracytosis to Aggravate Acute Inflammation

Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...

Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic B Cell Pyroptosis upon Viral Infection

Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...

Construction of Multilayered Small Intestine-like Tissue by Reproducing Interstitial Flow

Multilayered Tissue Construction of a Micro-intestinal System Reproduces Mesenchymal Flow Research Background In recent years, constructing in vitro models of the human small intestine has made significant progress; however, fully replicating its complex structural and functional characteristics remains challenging. The goal of micro-intestinal tis...

Stress-Induced Eosinophil Activation Contributes to Postoperative Morbidity and Mortality After Lung Resection

Research Background With global population aging, the number of lung resection surgeries has increased significantly, including primary lung cancer resection, removal of lung metastases, and surgeries to treat lung infections or emphysema. However, little is known about the systemic stress response after thoracic surgery and interventions to improv...

Semisynthetic Guanidino Lipoglycopeptides with Potent In Vitro and In Vivo Antibacterial Activity

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...