Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway

Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...

Compensation or Preservation? Different Roles of Functional Lateralization in Speech Perception of Older Non-Musicians and Musicians

The Impact of Music Training on Language Perception in Older Adults Under Global Aging Challenges Research Background As global population aging accelerates, the decline in language perception ability of older adults in noisy environments has become a notable issue. Older adults, even with normal hearing, often encounter the “cocktail party problem...

Alleviating CB2-dependent ER stress and mitochondrial dysfunction improves chronic cerebral hypoperfusion-induced cognitive impairment

Research Overview and Background With the acceleration of global aging, the incidence of ischemic cerebrovascular diseases is also rising significantly. Elderly people over 65 are particularly susceptible to cognitive decline caused by cerebral ischemia, making Chronic Cerebral Hypoperfusion (CCH) a major cause of cognitive impairment and Vascular ...

Perioperative levels of IL8 and IL18, but not IL6, are associated with nucleus basalis magnocellularis atrophy three months after surgery

Association Study of Perioperative IL8 and IL18 Levels with Brain Basal Ganglia Atrophy Three Months After Surgery Background In recent years, an increasing number of studies have shown that surgical procedures may accelerate brain atrophy. Meanwhile, the relationship between systemic inflammation and neurodegenerative diseases has also received co...

Longitudinal Associations Between Time Perspective and Life Satisfaction Across Adulthood

Research Report on the Long-term Relationship between Time Perspective and Life Satisfaction in Adulthood Research Background Time perspective is an important predictor of human well-being. However, time perspective itself changes with development. A future-dominated time perspective gradually gives way to a present and past-focused perspective as ...

Trend Change Analysis of Postural Balance in Parkinson’s Disease Discriminates Between Medication State

Analysis of Trend Changes in Static Balance of Parkinson’s Disease Patients to Distinguish Drug States Introduction Maintaining static body balance is crucial for daily living, which requires coordination between different body segments. Any change or decline in balance ability increases the risk of falling. Patients with Parkinson’s disease (PD) e...

Wearable Biofeedback Device to Assess Gait Features and Improve Gait Pattern in People with Parkinson’s Disease: A Case Series

Wearable Biofeedback Device to Assess Gait Features and Improve Gait Pattern in People with Parkinson’s Disease: A Case Series

Application of Wearable Biofeedback Device in Gait Assessment for Parkinson’s Disease Patients: A Case Series Study Research Background Patients with Parkinson’s Disease (PD) often exhibit abnormal gait patterns, severely affecting their independence and quality of life. Gait abnormalities primarily manifest as reduced stride length, increased step...

Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...

Microglia Undergo Sex-Dimorphic Transcriptional and Metabolic Rewiring During Aging

The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...

The Role of Dysregulated miRNA-140 and miRNA-122 in Alzheimer's Disease

Analysis and Potential Applications of miRNAs Related to Alzheimer’s Disease Background and Research Motivation Alzheimer’s Disease (AD) is a progressively worsening neurodegenerative disorder and the most common form of dementia among the elderly. The pathological features of AD in the brain primarily include senile plaques formed by the accumulat...