Reversal of Beige Fat Decline by Estrogen Through NAMPT-Regulated Endoplasmic Reticulum Stress Response Abstract: Brown adipocytes are valued for their potential therapeutic effects against metabolic diseases. However, the metabolic advantages provided by these cells deteriorate with age. Our research shows that treating mice with estrogen (E2), a ...
Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...
Scientific Research Report Background Introduction For a long time, aging has been considered an irreversible process. However, recent research suggests that aging is a biological process that can be regulated. Various interventions have been shown to delay or even reverse certain characteristics of aging. Partial reprogramming is a method that rev...
Small Extracellular Vesicles in Young Plasma Reverse Age-Related Functional Decline by Improving Mitochondrial Energy Metabolism Background In recent years, research on heterochronic parabiosis has revealed significant regenerative effects of young blood on elderly tissues. However, the specific regenerative mechanisms are not fully understood. Thi...
Study on Human Muscle Aging Reveals Impact of Short-term Exercise on Lipid Composition Research Background As the global population ages, understanding the physiological changes associated with aging has become a key focus in scientific research. Previous studies using animal models have indicated that complex lipids, such as phospholipids, play im...
In the global context, the Planetary Health Diet has been proposed as a way to improve human health while protecting the Earth. However, studies on the relationship between the Planetary Health Diet and cognitive decline are very limited. To fill this research gap, researchers Natalia Gomes Gonçalves, Leandro Teixeira Cacau, Naomi Vidal Ferreira, P...
Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...
Research Review on Aging-Exacerbated Metabolic Dysfunction-Related Lipid Liver Diseases Academic Background As the aging population increases, metabolic diseases induced by aging are becoming a severe public health challenge. The liver, being the primary metabolic organ, requires special attention to its functional disorders during aging. Studies h...
Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...
Clinical Aging Clock Based on Principal Components Reveals Characteristics of Healthy Aging and Targets for Clinical Interventions Background of the Study As the population ages, promoting healthy aging and slowing down biological aging has become an important issue. To accurately predict all-cause mortality and obtain feasible measures to promote ...