Mapping Medically Relevant RNA Isoform Diversity in the Aged Human Frontal Cortex with Deep Long-Read RNA-Seq

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
RNA isoforms   frontal cortex   long-read RNA sequencing   Alzheimer's disease   differential expression  

Academic Background RNA isoforms play a critical role in gene expression regulation. On average, human protein-coding genes contain over eight RNA isoforms, leading to nearly four distinct protein-coding sequences. Traditional short-read sequencing technologies, due to their limitations in read length, cannot accurately assemble and quantify RNA is...

Age-Related Changes in the Susceptibility to Visual Illusions of Size

Medicine, Geriatrics, Neurology,
Visual Perception   Aging   Visual Illusions   Size Perception  

As the global population ages, understanding the impact of aging on visual perception becomes increasingly important. This study investigates age-related changes in size perception in adults through three visual illusions: the Ponzo illusion, the Ebbinghaus illusion, and the height-width illusion. Based on a Bayesian model that conceptualizes the a...

Functional Connectivity Changes in Mild Cognitive Impairment: A Meta-Analysis of M/EEG Studies

Medicine, Geriatrics, Neurology, Clinical Psychology, Medical Imaging,
Mild Cognitive Impairment   Healthy Aging   Electrophysiology   EEG   MEG   Functional Connectivity   Alzheimer’s Disease  

Changes in Functional Connectivity in Mild Cognitive Impairment: A Meta-Analysis of M/EEG Studies Background and Objectives Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive impairment. AD is the leading cause of cognitive disorders in the elderly, accounting for approximately 60% to 80% of global c...

Magnetoencephalography-Derived Oscillatory Microstate Patterns Across Lifespan: The Cambridge Centre for Ageing and Neuroscience Cohort

Medicine, Psychiatry, Geriatrics, Neurology, Medical Imaging, Life Sciences, Biophysics,
machine learning   microstates   healthy aging   alpha  

Application of Magnetoencephalography (MEG) to Analyze Changes in Whole-Brain Oscillatory Microstate Patterns Across the Lifespan: Cambridge Centre for Aging and Neuroscience Cohort Study Research Background With the increasing seriousness of the aging population problem, understanding the neurophysiological changes during the aging process becomes...

Associations of Epigenetic Age Estimators with Cognitive Function Trajectories in the Women's Health Initiative Memory Study

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry, Genetics,
epigenetics   age estimation   cognitive function   women's health   memory  

Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...