Comparative Analysis of Recombinant Quadrivalent Influenza Vaccine and Standard Egg-Based Quadrivalent Influenza Vaccine in Nursing Home Residents: A Cluster Randomized Trial Academic Background Influenza is among the primary respiratory pathogens causing morbidity and mortality among the elderly worldwide, particularly in nursing home residents wh...
Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...
Lithocholic Acid Phenocopies Anti-Ageing Effects of Caloric Restriction Academic Background Caloric restriction (CR) is a dietary intervention used to promote health and longevity by reducing food intake. Although CR has been shown to extend the lifespan of various organisms, the specific metabolic mechanisms behind its effects remain unclear. In p...
Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys Background of the Study The ovary is a crucial organ for female reproduction and health, responsible for producing oocytes and secreting sex hormones. As women age, ovarian reserves gradually decline, eventually leading to menopause, which brings about...
Reversible Regulation of Retinal and Peripheral Nerve Function: Physiological Study of Serine and Glycine Background and Research Motivation Macular Telangiectasia Type 2 (Mactel) is an age-related retinal disease characterized by central vision loss. The molecular etiology of this disease is complex and is primarily associated with the metabolism ...
Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...
Intermittent Clearance of High p21-Expressing Cells Extends Lifespan and Delivers Sustained Health Benefits Research Background With the significant extension of human lifespan, the global elderly population is rapidly increasing. Elderly individuals often face decreased functionality and various chronic diseases in their later years, such as cardi...
Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...
Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...
Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...