New Insights into CNS Disease Immunology Mechanisms Revealed by Multidimensional Flow Cytometry In immunological research, understanding the immunopathological mechanisms of central nervous system (CNS) diseases is crucial for early diagnosis and treatment decisions. A study published in Journal of Neuroinflammation in 2024 used multidimensional fl...
Analysis of the Molecular Recognition and Signal Transduction Mechanism of PRRP and PRRPR Research Background Neuropeptides, as the most abundant signaling molecules in the nervous system, have over 100 identified types and play critical roles in processes like metabolism, pain sensation, and reproduction. Among them, RF-amide neuropeptides are cha...
Lipid Metabolism Mechanisms in Neurodegenerative Diseases: A New Study on Multiple Sclerosis Multiple Sclerosis (MS) is a common inflammatory autoimmune demyelinating disease of the central nervous system (CNS). As the disease progresses, patients gradually experience neurological damage and disability. Although there have been advances in the trea...
Disturbance of Neuronal Homeostasis and Disruption of Neuronal Network Dynamics Caused by Tau Proteinopathy Background and Research Objectives Homeostatic mechanisms play a crucial role in maintaining the stability of brain functions. Under normal circumstances, neuronal activity set-points, such as firing rates, are dynamically adjusted through ho...
A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...
A Mechanism of Brainstem Circuit Enhancing Aversion Response Background and Motivation Aversion response is a natural reaction in humans and animals when faced with threats or unpleasant stimuli, allowing individuals to avoid danger and playing a critical role in adaptation during evolution. However, excessive aversion can lead to a range of emotio...
This article is a biomedical research paper authored by scholars such as Zhang Tingxin, Bi Cheng, and Li Yiran, published on November 6, 2024, in the journal “Neuron.” The research was led by a team from the Tsinghua University-Peking University Center for Life Sciences, exploring the regulatory mechanism of phosphorylation modification of the mech...
The Neural Basis of Underperformance Under Pressure: An Analysis of the Interaction Between Reward Signals and Motor Preparation in Primate Brains Research Background “Choking under pressure” refers to situations where individuals fail to perform as expected due to the stress of important moments, as often seen with professional athletes during cri...
I. Research Background: Neoteny in Human Brain Development and Neurodevelopmental Disorders One of the remarkable features of human brain development is the slow developmental pace of cortical neurons. Compared to other mammals, especially non-human primates, the developmental process of human cortical neurons can last for several years. This neote...
Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...