Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...
Gene Variants and Altered Blood mRNA Levels as Risk Factors for Post-Stroke Cognitive Impairment in Indians Research Background Cognitive impairment is a common clinical outcome after stroke, occurring in about 30% of stroke survivors. Research has shown that Brain-Derived Neurotrophic Factor (BDNF) plays an important role in this process, and BDNF...
Alleviating Effect of EI-16004 on Astrocyte-Mediated Neuroinflammation in MPTP-Induced Parkinson’s Disease Model Background Introduction Parkinson’s Disease (PD) is a neurodegenerative disorder primarily affecting the elderly, characterized by tremors, bradykinesia, rigidity, and loss of postural reflexes, mainly due to the loss of dopaminergic neu...
Study on the Circadian Rhythm of Orexin System Genes and Their Impact on Early Alzheimer’s Disease (AD) Pathology Research Background and Objectives Alzheimer’s Disease (AD) is a chronic degenerative disease of the central nervous system, characterized by senile plaques formed by β-amyloid protein (Aβ) aggregation and neurofibrillary tangles formed...
Elevated IL-6 Levels and Upregulation of Iron-Regulatory Biomarkers Promote Japanese Encephalitis Virus Infection In this research paper, the authors explore changes in inflammatory response and iron-regulatory biomarkers during Japanese Encephalitis Virus (JEV) infection. A comprehensive analysis of iron-regulatory biomarkers and inflammatory resp...
A New Differential Diagnosis Method Based on miRNA Background Introduction Neuromuscular Disorders (NMDs) are a class of chronic diseases that consistently progress to muscle atrophy. Although certain diseases such as Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD), Congenital Muscular Dystrophy (CMD), Limb-Girdle Muscular Dystro...
Effects of Chronic Hypertension on Mitochondrial Energy Metabolism in the Cerebral Cortex of Normal and Spontaneously Hypertensive Rats Background Introduction Chronic hypertension has destructive structural and functional consequences for cerebral vessels and brain parenchyma. Hypertension impairs cerebrovascular autoregulation (Ferrari & Villa, 2...
Research Reveals Gender-Specific Epigenetic Regulatory Mechanisms in Neuroinflammation, Injury, and Recovery Background Ischemic stroke is one of the leading causes of death and disability worldwide. Due to limited understanding of its linked disease mechanisms, current treatments for alleviating acute ischemic brain injury are very limited. Recent...
Research Report on the Effects of Naringin Intervention on Newborn Neurons and BDNF Levels in Rat Brain Ischemia-Reperfusion Model Background With the global increase in cardiovascular diseases, ischemic stroke has gradually become a major cause of death and disability, affecting the quality of life of millions of people. Despite continuous advance...
Differential Regulation of miR206 and miR423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis Patients This article was published in the 2024 issue of “Neuromolecular Medicine,” titled “Differential Regulation of miR206 and 423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis (ALS) Patients.” The authors include ...