Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...
Research Progress on Early Alzheimer’s Stages: Focusing on Differences Between Objective Subtle Cognitive Difficulties and Subjective Cognitive Decline Alzheimer’s disease (AD) is a critical topic in modern neuroscience and geriatric medicine research. Its pathological process begins years before the onset of clinical symptoms. Increasing evidence ...
Multimodal Neuroimaging Study on Cognitive Impairment in Parkinson’s Disease Parkinson’s Disease (PD) is a common neurodegenerative disorder mainly characterized by motor impairments. However, cognitive impairment (CI), one of the non-motor symptoms, significantly affects patients’ quality of life. According to extensive epidemiological studies, ap...
Revealing Gene Expression Patterns Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy Background Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy, and its pathological features and mechanisms have long drawn extensive attention in the field of neuroscience. This disorder involves not only a single b...
Application of Explainable Machine Learning in Amino Acid PET Imaging for Glioma Diagnosis Academic Background Gliomas are among the most common malignant tumors of the central nervous system, with their diagnosis and treatment strategies typically relying on histopathological analysis. However, histopathology has limitations such as being highly i...
Early-phase 18F-Flortaucipir Tau-PET as a Proxy for Brain Metabolism in Alzheimer’s Disease Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by extracellular β-amyloid (Aβ) deposition, intracellular pathological tau protein accumulation, and neurodegeneration. These pathological changes begin accumulating in ...
A Neurofunctional Study of Tactile Feedback in Stroke Rehabilitation Based on fNIRS Academic Background Stroke is a common neurological condition that profoundly affects patients’ daily lives and quality of life. Among the various functional impairments caused by stroke, hand dysfunction is particularly notable, manifesting in decreased muscle stre...
Research Report on Automated Robotic Craniotomy Surgery System Background As the central organ of complex life activities, the brain governs all psychological and conscious processes, playing a crucial role in every aspect of life. Entering the 21st century, neuroscience has become one of the fastest-growing and most prominent fields, with animal m...
Super-Resolution Imaging Reveals New Advances in Neural Morphodynamics in Mouse Brains: Dynamic Observations in Head-Fixed Awake Animals Background In the field of neuroscience, understanding the morphological changes and functional dynamics of neurons is key to deciphering how the brain processes information and sustains network plasticity. Despit...
Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...