Glepaglutide-Loaded Foam for Inducing Mucosal Healing in Inflammatory Bowel Disease Treatment

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma

Research Report on Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely low survival rate, with a 5-year survival rate of less than 15%. The primary reasons are early tumor metastasis and high resistance to chemotherapy and ra...

The Direct and Indirect Inhibition of Proinflammatory Adipose Tissue Macrophages by Acarbose in Diet-Induced Obesity

Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

Relmβ Sets the Threshold for Microbiome-Dependent Oral Tolerance

The Key Role of RELMβ in Food Allergy Academic Background Food allergy (FA) is a common immune system disorder, particularly prevalent among children. The occurrence of food allergy is associated with abnormal immune responses to food antigens, especially the dysregulation of type 2 immune responses. Type 2 immune responses are typically defense me...

Crystalloid Volume Versus Catecholamines for Management of Hemorrhagic Shock During Esophagectomy: Assessment of Microcirculatory Tissue Oxygenation of the Gastric Conduit in a Porcine Model Using Hyperspectral Imaging

Study on Crystalloid Volume versus Catecholamine Strategies for Managing Hemorrhagic Shock during Esophagectomy Academic Background Esophageal cancer is a common malignant tumor worldwide, and surgical resection is one of the primary treatment methods. However, esophagectomy is a complex procedure involving two body cavities (thoracic and abdominal...

Utilizing Bifurcated Allogeneic Vein Grafts: A Novel Approach for Preventing Sinistral Portal Hypertension Following Pancreaticoduodenectomy. A 10-Year Before and After Study

Utilizing Bifurcated Allogeneic Vein Grafts to Prevent Sinistral Portal Hypertension Following Pancreaticoduodenectomy Academic Background Pancreatic cancer is a highly malignant tumor with a poor prognosis, with a 5-year survival rate of less than 10%. The early invasive growth of pancreatic cancer often involves the portal vein system, particular...

Comparison of Long-Term Survival of Neoadjuvant Therapy Plus Surgery Versus Upfront Surgery and the Role of Adjuvant Therapy for T1b-2N0-1 Esophageal Cancer: A Population Study of the SEER Database and Chinese Cohort

Comparative Study on Treatment Strategies for Esophageal Cancer Academic Background Esophageal cancer is one of the digestive system tumors with high incidence and mortality rates worldwide, particularly in Asia, where the incidence of esophageal squamous cell carcinoma (SCC) is notably prominent. Although significant progress has been made in the ...

Global, Regional, and National Patterns of Change in the Burden of Nonmalignant Upper Gastrointestinal Diseases from 1990 to 2019 and the Forecast for the Next Decade

Trends and Future Predictions of the Global Burden of Non-Malignant Upper Gastrointestinal Diseases Academic Background Non-malignant upper gastrointestinal diseases, including Peptic Ulcer Disease (PUD), Gastritis and Duodenitis (GD), and Gastroesophageal Reflux Disease (GERD), pose significant challenges to global healthcare systems. These condit...

Postcolitis Alterations in Dose-Dependent Effects of 5-HT1A Agonist Buspirone on Nociceptive Activity of the Raphe Magnus and Dorsal Raphe Neurons in Rats

The Role of 5-HT1A Agonist Buspirone in Pain Regulation in Postcolitis Rats Background In recent years, increasing clinical and experimental evidence has shown that the brain’s serotonin (5-HT) system plays a significant role in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IB...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...