A Human Omentum-Specific Intermesothelial Fibroblast Population Inhibits Adipogenesis by Secreting IGFBP2 Background and Research Objective With the growing prevalence of obesity and metabolic diseases, the plasticity and heterogeneity of adipose tissue have become research hotspots. Different regions of adipose tissue exhibit distinct metabolic ch...

Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...

Perinatal onset of mitochondrial CoQ10 deficiency due to COQ7 defect with cardiomyopathy and gastrointestinal obstruction Background Coenzyme Q10 (CoQ10) is a lipid-soluble molecule with antioxidant properties and a key component in electron transfer during oxidative phosphorylation in mitochondria. CoQ10 deficiency is a rare mitochondrial metaboli...

Antibiotic-Induced Intestinal Immunomodulation Alleviates Experimental Autoimmune Neuritis (EAN) Academic Background Guillain-Barré syndrome (GBS) is an acute autoimmune disease that causes inflammatory demyelination of peripheral nerves. As the most common cause of acute flaccid paralysis, its global annual incidence is 1-4 cases per 100,000 peopl...

Research on Alleviating Gastrointestinal Inflammation by Adjusting Intestinal Circadian Rhythm through Feeding Time Background Information Impaired expression of intestinal circadian rhythm genes has been observed in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, such as that occurring in shift worker...

In recent years, increasing evidence from research on Inflammatory Bowel Disease (IBD) has shown that neutrophils play a crucial role in the occurrence and development of intestinal inflammation. IBD includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), and while its pathogenesis is not yet fully understood, abnormal immune responses are clear...

Achieving Synergistic Antitumor Activity by Dual Blocking of CCR1 and CXCR2 Expression in Myeloid Cells Background Introduction Colorectal Cancer (CRC) poses a global health crisis, with its incidence and mortality rates rapidly rising in recent years. Over the past 15 years, the mortality rate of CRC has increased by more than 30%, and it is expec...

Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...

Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...

The Relationship Between Autoimmune Diseases and Gastric Cancer Risk in the British Population Background Introduction Despite the overall incidence of gastric cancer has declined over the past few decades, the incidence of gastric cancer among young people in some Western countries has increased in recent years. This trend may be related to the in...