Achieving Healthy Aging through Gut Microbiota-Directed Dietary Intervention: Focusing on Microbial Biomarkers and Host Mechanisms Academic Background With the intensification of global population aging, preventing age-related diseases and extending healthy life expectancy have become critical issues in global public health. Gut microbiota has been...

Targeted Drug Delivery Using Self-Unrolling Sheets in Magnetically Actuated Capsules Background Gastrointestinal (GI) diseases, such as inflammatory bowel disease, GI bleeding, and cancer, are significant global health issues. Traditional treatment methods, such as endoscopy and oral medications, though effective to some extent, have many limitatio...

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

Research Report on Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely low survival rate, with a 5-year survival rate of less than 15%. The primary reasons are early tumor metastasis and high resistance to chemotherapy and ra...

Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

The Key Role of RELMβ in Food Allergy Academic Background Food allergy (FA) is a common immune system disorder, particularly prevalent among children. The occurrence of food allergy is associated with abnormal immune responses to food antigens, especially the dysregulation of type 2 immune responses. Type 2 immune responses are typically defense me...

Study on Crystalloid Volume versus Catecholamine Strategies for Managing Hemorrhagic Shock during Esophagectomy Academic Background Esophageal cancer is a common malignant tumor worldwide, and surgical resection is one of the primary treatment methods. However, esophagectomy is a complex procedure involving two body cavities (thoracic and abdominal...

Utilizing Bifurcated Allogeneic Vein Grafts to Prevent Sinistral Portal Hypertension Following Pancreaticoduodenectomy Academic Background Pancreatic cancer is a highly malignant tumor with a poor prognosis, with a 5-year survival rate of less than 10%. The early invasive growth of pancreatic cancer often involves the portal vein system, particular...

Comparative Study on Treatment Strategies for Esophageal Cancer Academic Background Esophageal cancer is one of the digestive system tumors with high incidence and mortality rates worldwide, particularly in Asia, where the incidence of esophageal squamous cell carcinoma (SCC) is notably prominent. Although significant progress has been made in the ...

Trends and Future Predictions of the Global Burden of Non-Malignant Upper Gastrointestinal Diseases Academic Background Non-malignant upper gastrointestinal diseases, including Peptic Ulcer Disease (PUD), Gastritis and Duodenitis (GD), and Gastroesophageal Reflux Disease (GERD), pose significant challenges to global healthcare systems. These condit...