Myeloid Beta-Arrestin 2 Depletion Alleviates Metabolic Dysfunction-Associated Steatohepatitis through Metabolic Reprogramming of Macrophages

The Loss of β-arrestin 2 in Hepatic Macrophages Alleviates Metabolic Dysfunction-associated Steatohepatitis — Through Metabolic Reprogramming of Macrophages Background and Motivation Metabolic dysfunction-associated fatty liver disease (MASLD) is a globally prevalent health issue, affecting approximately 25% of the population. This disease includes...

SGLT2 Inhibitor Promotes Ketogenesis to Improve MASH by Suppressing CD8+ T Cell Activation

SGLT2 Inhibitor Promotes Ketogenesis to Improve MASH by Suppressing CD8+ T Cell Activation

Research on SGLT2 Inhibitors Alleviating MASH by Enhancing Ketogenesis to Inhibit CD8+ T Cell Activation Research Background and Problem Positioning Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has become a global health concern. Its severe stage, Metabolic Dysfunction-Associated Steatohepatitis (MASH), leads to hepatocyte damag...

IL-22 Resolves MASLD via Enterocyte STAT3 Restoration of Diet-Perturbed Intestinal Homeostasis

IL-22 Restores Gut Homeostasis and Alleviates Diet-Induced MASLD In recent years, the incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has significantly increased, closely related to the widespread consumption of high-energy diets rich in sugars and fats. MASLD is not only closely linked to metabolic diseases such as ob...

The Therapeutic Potential of Ferroterminator1 in Treating Metabolic Dysfunction-Associated Steatohepatitis

Comprehensive Clinical and Preclinical Studies Reveal the Therapeutic Potential of Ferroterminator1 (FOT1) for Metabolic-Associated Fatty Liver Disease (MAFLD) Background: Research Needs on MAFLD and Iron Overload Issues Metabolic-associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common chroni...

In Vivo Bruton's Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis

Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...

Comprehensive Characterization and Global Transcriptome Analysis of Human Fetal Liver Terminal Erythropoiesis

Comprehensive Characterization and Transcriptome Analysis of Terminal Erythropoiesis in Human Fetal Liver Background and Research Question Erythropoiesis is the process of red blood cell production. Initially, “primitive” erythropoiesis occurs in the yolk sac, gradually replaced by “terminal” erythropoiesis in the fetal liver (FL) and postnatal bon...

Novel Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction

Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction Introduction Sepsis, especially severe cases, causes multiple organ dysfunction due to systemic infection, resulting in up to 5 million deaths globally each year. Traditionally, Sepsis-Associated Liver Dysfunction (SALD) was considered a condition accompanied by jaundice ...

Transketolase Promotes MAFLD by Limiting Inosine-Induced Mitochondrial Activity

Background Introduction Metabolic dysfunction-associated fatty liver disease (MAFLD) is a globally prevalent chronic liver disease with an incidence rate of about 25%. Its prevalence is even higher among obese and type 2 diabetic populations. MAFLD is a complex systemic disease that can progress from metabolic-associated fatty liver (MAFL) to metab...

TM7SF3 Controls TEAD1 Splicing to Prevent MASH-Induced Liver Fibrosis

Background Introduction In modern society, metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD) is a common and serious chronic liver disease. However, the current understanding of its pathological mechanisms is not complete, including its progression to metabolic dysfunction-associated steatohepatitis (MASH), liver fi...

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Background This paper aims to explore the function of somatic PKD1 mutations in cirrhosis and their impact on liver health without inducing cancer. The authors conducted this research because, although somatic mutations accumulate in non-malignant tissues and increase with age, it remains unclear whether these mutant clones are beneficial for organ...