Long-Term Outcomes of High-Risk Medulloblastoma Treatment Background Medulloblastoma is one of the most common malignant brain tumors in children. Despite advancements in treatment, the prognosis for high-risk medulloblastoma patients remains poor. High-risk medulloblastoma typically includes patients with metastatic disease, TP53 mutations, MYC/MY...

Clinical and Biological Heterogeneity in MYC/MYCN-Amplified Medulloblastoma Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Despite recent advances in treatment, approximately 30% of patients still die from the disease, and survivors often face long-term treatment-related complications. Amplifi...

Study on Relapse Patterns of Intracranial Ependymoma Background Ependymoma (EPn) is a rare but highly heterogeneous central nervous system tumor, particularly common in children. Despite significant advances in the biology and molecular characteristics of ependymoma in recent years, its relapse patterns remain unclear. The timing and location of re...

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

Study of Structural Variation in MECP2 Duplication Syndrome and Its Phenotypic Variability Academic Background MECP2 Duplication Syndrome (MRXSL) is an X-linked genomic disorder primarily caused by an increase in the copy number of the MECP2 gene on the X chromosome. This condition predominantly affects males, and its clinical features vary widely,...

This study explores the necessity of quickly recognizing and avoiding predators in the natural environment, which is crucial for juvenile animals due to their increased vulnerability to predators. However, it remains unclear whether neonatal vertebrates can rapidly acquire such skills and the underlying neural mechanisms. Zebrafish, a widely used m...

Academic Report on the Study of Layer-Specific Anatomical and Physiological Characteristics of the Retinal Neurovascular Unit Background and Problem Statement Retinal processing, similar to all neural computations, is metabolically expensive and involves the dynamic regulation of blood flow, known as neurovascular coupling (NVC). The retina is supp...

Report on the Study of the Impact of ANCV1R Gene Deficiency on Pheromone Detection and Sexual Behavior in Mice Background Introduction In mammals, pheromones are crucial chemical signals that regulate social and sexual behaviors. Pheromone detection is mediated by the vomeronasal organ (VNO), which uses vomeronasal sensory neurons (VSNs) to recogni...

Innovative Advances in Wearable Single-Transducer Echomyography Systems: From Muscle Dynamics Monitoring to Complex Gesture Tracking Academic Background and Research Significance In recent years, wearable electronic devices have garnered significant attention for their enormous potential in health monitoring and human-machine interaction. Electromy...

Repeated Exposure to Sevoflurane Impairs GABAergic Neuronal Development and Social Cognitive Function in the Hippocampal CA2 Region of Mice Academic Background Approximately 1.5 million infants and young children undergo medical procedures requiring general anesthesia annually, with sevoflurane being widely used in pediatric anesthesia. However, in...