rh-relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats Academic Background Germinal Matrix Hemorrhage (GMH) is one of the most common neurological disorders in newborns, particularly in preterm infants, and is a major cause of brain injury. GMH not only triggers acute inf...

Study on Cerebrospinal Fluid Dynamics Following Traumatic Spinal Cord Injury in a Porcine Model Background Traumatic Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to permanent neurological dysfunction. Despite years of efforts by scientists to develop treatments, progress has been limited due to the complex pathophysio...

Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the deposition of β-amyloid (Aβ) plaques and the aggregation of hyperphosphorylated microtubule-associated protein tau (tau). These pathological changes lead to gra...

Chronic Cerebral Ischemia and Its Association with Normal Pressure Hydrocephalus Academic Background Normal Pressure Hydrocephalus (NPH) is a potentially reversible dementia characterized by cognitive impairment, gait disturbance, and urinary incontinence. Despite only a mild increase in intracranial pressure (ICP, approximately 15 mmHg), patients ...

The Role of Brain Barriers in Brain Metastasis Background Introduction Brain metastases (BMs) are the most common intracranial tumors in adults, occurring 3 to 10 times more frequently than primary brain tumors. Despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy, the prognosis for brain metastases remains poo...

Non-invasive Quantification of Cerebrospinal Fluid Dynamics and Ventricle-Subarachnoid Space Pressure Gradient Background Cerebrospinal fluid (CSF) is a vital component of the central nervous system, providing protection to brain tissue, maintaining intracranial pressure stability, and facilitating the clearance of metabolic waste. Abnormal CSF cir...

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...

Improving the Accuracy of Brain Image Analysis in Patients with Idiopathic Normal Pressure Hydrocephalus Using Customized Tissue Probability Maps and Templates Academic Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a common neurological disorder characterized by gait disturbance, cognitive decline, and urinary incontinence. One of t...

New Method for Studying the Coupling Between Cerebrospinal Fluid Flow and Cortical BOLD Signals Academic Background In recent years, the role of cerebrospinal fluid (CSF) in brain waste clearance has garnered significant attention. Traditionally, CSF was thought to primarily serve as a cushion and provide immune surveillance. However, growing evide...

Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...