Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

Medicine, Environmental and Public Health, Neurology, Pharmacy,
pharmaceutical neuroenhancements   public views   regulation   societal effects   individual effects  

Research Report on Whether the Public Should Be Allowed to Use Drug Enhancers Introduction In recent years, some individuals have started using drugs to enhance cognitive and socio-emotional functions and have requested off-label prescriptions from doctors for neuroenhancement (e.g., stimulants). However, discussions about whether such uses should ...

Efficacy of Ofatumumab and Teriflunomide in Patients with Relapsing MS from Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses

Medicine, Rheumatology and Immunology, Neurology,
Ofatumumab   Teriflunomide   Relapsing Multiple Sclerosis   Racial/Ethnic Minority Groups   ASCLEPIOS Trials   No Evidence of Disease Activity  

Academic Paper Report Academic Background Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system characterized by the destruction of myelin and axons, leading to neurological dysfunction and progressive disability. It is estimated that there are approximately 2.8 million MS patients worldwide, with over 700,000 affected in...

Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Medicine, Geriatrics, Neurology, Cardiovascular System,
body composition   cardiovascular disease   neurodegenerative disease   UK Biobank   obesity  

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Parkinson's disease   brain network   α-synuclein   diffusion-weighted imaging   network resilience  

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Electroencephalography-Guided Anesthesia and Delirium in Older Adults after Cardiac Surgery

Medicine, Psychiatry, Geriatrics, Anesthesiology, Neurology, Cardiovascular System,
Electroencephalography   Anesthesia   Older Adults   Cardiac Surgery   Delirium  

EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...

A Comprehensive Overview of NF1 Mutations in Iranian Patients

Medicine, Medical Laboratory Science, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
NF1   mutation   Iranian   whole-exome sequencing   genetic counseling  

Comprehensive Overview of Mutations in Neurofibromatosis Type 1 Among Iranian Patients Neurofibromatosis type 1 (NF1) is a hereditary disease caused by mutations in the NF1 gene, characterized by almost complete penetrance and high phenotypic variability. This study aims to identify NF1 mutations in Iranian patients using whole-genome exome sequenc...

Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascular dementia   astaxanthin   Alzheimer’s disease   neurodegenerative diseases   neuronal apoptosis  

Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...

Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach

Medicine, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
α-synuclein   gut microbes   metabolites   protein-protein interaction   therapeutic agent   parkinsonian mice model  

Study on the Protective Effects of Medicinal Microorganisms on Parkinson’s Disease Background Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra region of the brain. The aggregation of α-synuclein is a crucial factor in the pathogenesis of Park...

Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice

Medicine, Geriatrics, Neurology, Sports Medicine, Life Sciences, Cell Biology, Biochemistry,
swimming   physical activity   dementia   synapses   brain  

A scientific paper authored by Ricardo Augusto Leoni de Sousa and his research team was published in Volume 26, Issue 31 of the journal “Neuromolecular Medicine” in 2024. The paper is titled “Physical exercise inhibits cognitive impairment and memory loss in aged mice, and enhances pre- and post-synaptic proteins in the hippocampus of young and age...