Serum Neurofilament Light Chain and Cognitive Performance in Women with and without HIV: A Longitudinal Study Over Approximately 8 Years Research Background With the widespread use of highly active antiretroviral therapy (ART), the life expectancy of individuals infected with human immunodeficiency virus (HIV) has significantly increased. However, ...
Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases Academic Background Neurodegenerative diseases (such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease) are characterized by neuronal death and gradual loss of function, leading to the deterioration of cognitive, ...
Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study Academic Background Introduction Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor, accounting for nearly 50% of all primary brain tumors in adults. It primarily originates from astro...
The Effect of Calcium Channel Blocker Nimodipine on Human Spinal Reflex Pathways Academic Background Motor control is one of the essential functions of the nervous system, and spinal reflex pathways play a key role in this process. In animal studies, voltage-sensitive calcium channels (VSCCs) have been identified as critical factors in regulating t...
A Cross-Tissue Transcriptome-Wide Association Study Identifies New Susceptibility Genes for Insomnia Background Insomnia is the second most prevalent psychiatric disorder, affecting nearly one-third of the global population. It not only diminishes quality of life but also increases the risk of cardiovascular diseases, metabolic disorders, mood diso...
Transspinal Stimulation Downregulates Flexion Reflex Pathways During Walking in Healthy Humans Academic Background Human walking is a complex motor process involving the coordinated work of the central and peripheral nervous systems. The spinal cord, as a crucial part of the central nervous system, plays a key role in controlling motor reflexes and...
Human Hand Movement Control—Differences in Kinematics Between Functional Object Manipulation and Grasping Actions Academic Background The functionality of the human hand plays a crucial role in daily life, particularly through its dexterity, which allows us to use tools to complete various complex tasks. However, millions of people lose hand functi...
The Impairment of Deviant Detection in the Auditory Cortex by the Serotonergic Psychedelic DOI Research Background Psychedelics are a class of psychoactive substances capable of significantly altering perception, cognition, and mood. They have recently regained attention due to their potential therapeutic value, such as in treating depression and a...
Study on Orientation-Tuned Gain Control Mechanisms in the Visual Cortex Academic Background Visual perception is a complex neural process influenced by contextual environments. Surround suppression is an important phenomenon that describes how the perceived contrast of a stimulus is attenuated when surrounded by other stimuli. The neural mechanisms...
The Impact of Aging on Implicit Motor Learning and Short-term Memory: A Study Based on Force Field Adaptation Research Background Motor adaptation is the process by which the brain adjusts motor strategies in response to environmental changes, typically involving two mechanisms: explicit learning and implicit learning. Explicit learning is a rapid,...