Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011–2022

Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences,
Primary Progressive Aphasia   Primary Progressive Apraxia of Speech   Epidemiology   Prospective Study   Radiographic Characteristics  

Study on the Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County (2011-2022) Background and Study Objectives Primary Progressive Aphasia (PPA) and Primary Progressive Apraxia of Speech (PPAOS) are rare neurodegenerative diseases that respectively lead to the degeneration of language abilities and spe...

Sex-Specific Association of Cardiovascular Risk Factors with Migraine: The Population-Based Rotterdam Study

Medicine, Environmental and Public Health, Neurology, Cardiovascular System,
Cardiovascular Risk Factors   Migraine   Sex Differences   Population Study   Rotterdam Study   Middle-aged   Elderly  

Research Report on Gender-Specific Association Between Cardiovascular Risk Factors and Migraine Academic Background Migraine is a common neurological disorder. Previous studies have shown that migraine, especially migraine with aura, is associated with cardiovascular events such as myocardial infarction, coronary heart disease, and cardiovascular m...

Graded Multidimensional Clinical and Radiologic Variation in Patients with Alzheimer Disease and Posterior Cortical Atrophy

Medicine, Geriatrics, Neurology, Clinical Psychology, Medical Imaging,
Alzheimer Disease   Posterior Cortical Atrophy   Cognitive Impairments   Brain Volumes   Neuroimaging  

Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...

Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

Medicine, Environmental and Public Health, Neurology, Pharmacy,
pharmaceutical neuroenhancements   public views   regulation   societal effects   individual effects  

Research Report on Whether the Public Should Be Allowed to Use Drug Enhancers Introduction In recent years, some individuals have started using drugs to enhance cognitive and socio-emotional functions and have requested off-label prescriptions from doctors for neuroenhancement (e.g., stimulants). However, discussions about whether such uses should ...

Efficacy of Ofatumumab and Teriflunomide in Patients with Relapsing MS from Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses

Medicine, Rheumatology and Immunology, Neurology,
Ofatumumab   Teriflunomide   Relapsing Multiple Sclerosis   Racial/Ethnic Minority Groups   ASCLEPIOS Trials   No Evidence of Disease Activity  

Academic Paper Report Academic Background Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system characterized by the destruction of myelin and axons, leading to neurological dysfunction and progressive disability. It is estimated that there are approximately 2.8 million MS patients worldwide, with over 700,000 affected in...

Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Medicine, Geriatrics, Neurology, Cardiovascular System,
body composition   cardiovascular disease   neurodegenerative disease   UK Biobank   obesity  

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Parkinson's disease   brain network   α-synuclein   diffusion-weighted imaging   network resilience  

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Electroencephalography-Guided Anesthesia and Delirium in Older Adults after Cardiac Surgery

Medicine, Psychiatry, Geriatrics, Anesthesiology, Neurology, Cardiovascular System,
Electroencephalography   Anesthesia   Older Adults   Cardiac Surgery   Delirium  

EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...

A Comprehensive Overview of NF1 Mutations in Iranian Patients

Medicine, Medical Laboratory Science, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
NF1   mutation   Iranian   whole-exome sequencing   genetic counseling  

Comprehensive Overview of Mutations in Neurofibromatosis Type 1 Among Iranian Patients Neurofibromatosis type 1 (NF1) is a hereditary disease caused by mutations in the NF1 gene, characterized by almost complete penetrance and high phenotypic variability. This study aims to identify NF1 mutations in Iranian patients using whole-genome exome sequenc...