International Consensus on Resistance, Rebound, and Recurrence in Pediatric Low-Grade Glioma with MAPK Inhibition Therapy: Established Using a Modified Delphi Method Academic Background Pediatric low-grade glioma (PLGG) is the most common type of tumor in the central nervous system of children. Although these tumors have a relatively high overall s...

Study on Metabolic Differences between IDH Mutant and Wild-type Glioma Cells Using Raman Spectroscopy and Machine Learning Platform Background Introduction In the diagnosis and treatment of gliomas, formalin-fixed, paraffin-embedded (FFPE) tissue sections are commonly used. However, due to background noise interference from the embedding medium, th...

Microcirculatory Disorders of Cerebral Blood Flow and the Hypoxic-Ischemic Microenvironment Related to Brain Metastasis Development Background and Research Motivation Brain metastasis (BM) is an increasing challenge in oncology due to its severe impact on neurological function, limited treatment options, and resulting poor prognosis. BM develops th...

Analysis of Risk Factors Related to Specific Domain Neurocognitive Outcomes in Pediatric Survivors of Posterior Fossa Brain Tumors – HIT 2000 Trial Results Research Background Brain tumors are the most common solid tumors in childhood, particularly central nervous system (CNS) tumors. Studies have shown that patients who receive craniospinal irradi...

Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...

Orthogonal Proteogenomic Analysis Identifies Druggable PA2G4-MYC Axis in 3q26 AML Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive malignancy. In particular, the 3q26 chromosomal abnormality subtype of AML has a complex pathogenic mechanism and lacks effective targeted therapies. To address this challenge, Matteo Marchesini and...

Acetate Reprograms Tumor Metabolism and Promotes Immune Evasion and PD-L1 Expression by Upregulating c-myc Introduction Reprogramming of tumor metabolism is of great significance in cancer research, and acetate plays a crucial role in this process. In tumor cells, acetate is an important precursor of acetyl-CoA, which is used for energy production,...

Scientific Paper Report Discoveries in the field of science often have significant implications for understanding natural phenomena and improving practical applications. Recently, a research paper published in Science Immunology titled “Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-...

Heart Failure Promotes Multimorbidity through Innate Immune Memory Research Background Despite significant medical advances, the mortality rate of heart failure (HF) remains high, necessitating new therapeutic targets. HF patients often experience acute decompensation and develop comorbidities such as chronic kidney disease and frailty syndrome. Th...

Interaction and Attenuation of Tumor-Specific CD8+ T Cell Responses by LRIG1 and VISTA Academic Background In recent years, the importance of immune checkpoint inhibitors (ICIs) such as Programmed Cell Death Protein 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) has received increasing attention. These inhibitors significantly improve the s...