TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma Academic Background Lung adenocarcinoma (LUAD) is one of the most common subtypes of non-small cell lung cancer (NSCLC), with frequent mutations in the epidermal growth factor receptor (EGFR). Since 2013, EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and o...

Academic Research Report: MCL1 Copy Number Gain as a Therapeutic Target for Osteosarcoma Academic Background Osteosarcoma (OS) is a primary malignant bone tumor that predominantly affects children and adolescents. Although the treatment regimen combining surgery with chemotherapy was established in the 1970s and remains the standard therapy, progre...

TRIB3 Promotes Multiple Myeloma Progression by Stabilizing SSRP1 via USP10-Mediated Deubiquitination Academic Background Multiple Myeloma (MM) is the second most common hematologic malignancy globally, characterized by aggressive progression, frequent relapse, and resistance to therapy. Although current multi-drug combination therapies have signifi...

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression Academic Background Ovarian cancer (OC) is one of the most lethal cancers in the female reproductive system, with complex pathogenesis and limited treatment options. The epidermal growth factor receptor (EGFR) signaling pathway is widely dysregulated in various can...

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...

Metabolic Rewiring Controlled by HIF-1α Tunes IgA-Producing B-Cell Differentiation and Intestinal Inflammation Background Introduction Germinal centers (GC) are critical sites for the clonal expansion of immune B cells and the affinity maturation of antibodies, as well as the occurrence of antibody class switching. Within the GC, B cells undergo so...

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

Review of the Study “Esophageal ILC2s Mediate Abnormal Epithelial Remodeling in Eosinophilic Esophagitis via AREG-EGFR Signaling” Background Overview Eosinophilic Esophagitis (EoE) is a chronic allergic disease that has shown a significant increase in prevalence in recent years. It is characterized by eosinophil infiltration and epithelial thickeni...

Digital Spatial Transcriptomics Highlights DTX3L and BST2 as Crucial Biomarkers in Esophageal Squamous Cell Carcinoma Tumorigenesis Background and Research Question Esophageal cancer (EC) remains a globally prevalent malignant disease with high incidence and mortality rates. Esophageal squamous cell carcinoma (ESCC), the most common histological su...

Report on a Study of the Dynamics of Carriage, Acquisition, and Transmission of ESBL-Producing E. coli (ESBL-EC) in Non-ICU Hospital Wards Over Two Years Antimicrobial resistance is an increasingly significant global public health issue, with the rapid dissemination of extended-spectrum beta-lactamase-producing (ESBL) Enterobacterales, such as Kleb...