Bone Marrow-Derived NGFR+ Dendritic Cells Regulate Arterial Remodeling Background Introduction Atherosclerosis is the primary pathological basis of cardiovascular disease, and its incidence continues to rise globally. Although extensive research has revealed the pathogenesis of atherosclerosis and led to the development of various therapeutic drugs...

Syntaxin 4-Enhanced Plasma Membrane Repair is Independent of Dysferlin in Skeletal Muscle Background Introduction Plasma membrane repair (PMR) is a crucial process for cells to maintain membrane integrity, preventing cell death, especially in vital organs such as skeletal muscle. Dysferlin, a sarcolemmal calcium-binding protein, has been shown to p...

Mechanism Study of p300 Maintaining Primordial Follicle Activation by Inhibiting VEGFA Transcription Academic Background In the female reproductive system, primordial follicles (PFs) are the earliest formed follicles in the ovary, remaining dormant and awaiting activation to enter the growth phase. The activation of primordial follicles is a key fa...

Mechanism Study of Dapagliflozin Improving Diabetic Nephropathy via the Gut-Kidney Axis Academic Background Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, with approximately 40% of individuals with type 1 or type 2 diabetes developing DN in the advanced stages of the disease. Although clinical managemen...

Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation Academic Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder that ultimately leads to end-stage renal disease. ADPKD primarily arises from mutations in the PKD1 and PKD2 genes, which encode Polycystin 1 ...

Histone Lactylation Promotes Endometriosis Progression by Upregulating CTPS1 SUMOylation Academic Background Endometriosis is a common reproductive endocrine disease affecting approximately 10% of women of reproductive age worldwide. Its main symptoms include dysmenorrhea, chronic pelvic pain, infertility, and menstrual abnormalities. Although the ...

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...

Application of Multiresolution Signal Wavelet Network in Speech Emotion Recognition: SigWavNet Academic Background Speech Emotion Recognition (SER) plays a crucial role in human-computer interaction and psychological assessment. It identifies the speaker’s emotional state by analyzing speech signals, with wide applications in emergency call centers...

Research on Empathetic Response Generation in AI Dialogue Systems Academic Background With the rapid development of artificial intelligence technology, open-domain dialogue systems have gradually become a research hotspot. These systems aim to engage in natural and fluent conversations with users, providing reasonable responses. However, despite si...

Application of Text-Guided Reconstruction Network in Multimodal Sentiment Analysis Academic Background Multimodal Sentiment Analysis (MSA) is a research field that aims to integrate sentiment expressions from text, visual, and acoustic signals. With the abundance of user-generated online content, MSA demonstrates significant potential for improving...