PD-L1 in Tumor-Derived Extracellular Vesicles Promotes T Cell Senescence through Lipid Metabolism Reprogramming Academic Background In recent years, immunotherapy has shown great promise in cancer treatment, particularly in checkpoint blockade therapies targeting PD-1/PD-L1 (programmed cell death protein 1 and its ligand) and CTLA-4 (cytotoxic T-ly...
Breakthrough in Gene Therapy: Repair Drive Technology Enables In Vivo Expansion of Hepatocytes Academic Background Gene therapy has become a hot topic in medical research in recent years, especially for liver diseases. Due to the central role of the liver in metabolism, it has become a critical target for research. Although existing gene-editing te...
Mechanism of Combined Immune Checkpoint Blockade Therapy Academic Background Immune Checkpoint Blockade (ICB) is a revolutionary cancer treatment aimed at reactivating effector T cells to combat cancer. However, more than half of patients do not respond to ICB, especially those with immunologically “cold” tumors (tumors with fewer immune cells in t...
Amyloid-Associated Hyperconnectivity Drives Tau Spread in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and the abnormal aggregation and spread of tau protein in the brain. The traditional “amyloid cascade hypothesis” posits that...
Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...
Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...
Research on Ciliary Diseases: The Role of CCDC39/CCDC40 Heterodimer in Primary Ciliary Dyskinesia Academic Background Primary Ciliary Dyskinesia (PCD) is a rare monogenic disorder characterized by chronic respiratory infections, infertility, and organ laterality defects. Although more than 50 genes associated with PCD have been identified, mutation...
Mechanisms and Therapeutic Exploration of Early Sleep Abnormalities in Patients with Amyotrophic Lateral Sclerosis Academic Background Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the degeneration of motor neurons, leading to progressive muscle weakness and respiratory failure. Although the primary symptoms ...
Academic Background NRAS-mutant (NRASmut) melanoma is a highly aggressive tumor type, accounting for nearly 30% of all melanoma cases. NRAS is an oncogene that persistently activates the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a critical role in melanoma development. However, despite extensive research on MAPK pathway...
Pseudomonas aeruginosa Infection Induces Antibody-Mediated Rejection in Lung Transplantation Academic Background Introduction Lung transplantation is a critical treatment for end-stage lung diseases, but post-transplant rejection remains a major challenge affecting long-term patient survival. Antibody-mediated rejection (AMR) is an increasingly rec...