Quantifying the Impact of Air Pollution from Coal-Fired Electricity Generation on Crop Productivity in India

Impact of Air Pollution from Coal-Fired Electricity Generation on Crop Productivity in India Academic Background India is one of the world’s largest agricultural producers and also one of the most air-polluted countries. Coal-fired power generation is a primary source of electricity supply in India, but the air pollutants it generates, especially n...

Fixational Eye Movements as Active Sensation for High Visual Acuity

Fixational Eye Movements as Active Sensation for High Visual Acuity Academic Background Human visual perception is a complex process, especially when we attempt to maintain stable gaze. Even then, the eyes still produce small involuntary movements known as fixational eye movements (FEM). These FEM typically include drifts and microsaccades. Previou...

Intracranial Substrates of Meditation-Induced Neuromodulation in the Amygdala and Hippocampus

Study on the Neuroregulatory Effects of Meditation: A Case Study of Loving-Kindness Meditation Academic Background Meditation, as a mental training technique, has long been believed to regulate emotions and enhance mental health. Specifically, Loving-Kindness Meditation (LKM), which focuses on cultivating positive emotions towards oneself and other...

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Multi-Ancestry Genome-Wide Association Study Reveals New Loci for Prostate-Specific Antigen Levels and Improves Prediction Across Ancestral Groups Research Background and Problem Statement Prostate-specific antigen (PSA) is a protein secreted by the prostate gland, commonly used for prostate cancer screening. However, PSA levels are influenced not ...

Mechanistic Insights into Inactivating Mutations in the Proton-Coupled Folate Transporter (SLC46A1), and Compensatory Mutations that Restore Function

Research Background and Problem Statement Hereditary Folate Malabsorption (HFM) is a rare autosomal recessive disorder characterized by impaired intestinal absorption of folates and hindered transport across the choroid plexus into cerebrospinal fluid. This disease is caused by inactivating mutations in the gene encoding the Proton-Coupled Folate T...

A Statistical Framework for Multi-Trait Rare Variant Analysis in Large-Scale Whole-Genome Sequencing Studies

A New Framework for Multi-Trait Rare Variant Analysis: Multistaar Research Background and Problem Statement With the advancement of next-generation sequencing technologies and the decreasing cost of whole-genome sequencing (WGS), researchers can delve deeper into the impact of rare variants on complex human traits. However, single-trait analysis me...

The Association of Physical Activity Fragmentation with All-Cause Mortality in Hispanics: A Prospective Cohort Study

Research Background and Question In modern society, the patterns of physical activity (PA) and their impact on health have been a critical area of public health and medical research. Traditional studies have primarily focused on the total volume and intensity of physical activity. However, in recent years, an increasing number of studies have begun...

The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa

Research Background Current Status and Challenges in Hidradenitis Suppurativa Research Hidradenitis Suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. It affects approximately 1% of the global population, disproportionately impacting women and marginalized groups. HS’s pathogenesis is complex, involving genetic, im...

Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients

Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients Academic Background and Research Motivation During the treatment of active tuberculosis (Tuberculosis, TB), patients often experience tachycardia (Tachycardia), which typically diminishes as they recover. Elevated heart ...

Same Data, Different Analysts: Variation in Effect Sizes Due to Analytical Decisions in Ecology and Evolutionary Biology

Same Data, Different Analysts: The Impact of Analytical Decisions on Effect Sizes in Ecology and Evolutionary Biology Research Background and Question In scientific research, particularly in the fields of ecology and evolutionary biology, the replicability and reliability of results are crucial. However, even when using the same dataset and similar...