O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-DOPA Levels Research Background In the nervous system, dopamine is a key neurotransmitter, and the rate-limiting enzyme in its synthesis pathway is tyrosine hydroxylase (TH). The activity of TH is regulated by various post-translational modifications (PTMs), among which ...
Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease via Endothelial LAG3 Endocytosis Academic Background Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the abnormal formation and transmission of α-synuclein (α-syn). Recent studies have ...
Modeling of Ion and Water Transport on the Human Ocular Surface Background Introduction The ocular surface plays a crucial role in human physiology and diseases, especially the stability and composition of the tear film, which directly impact ocular surface health. The tear film consists of three layers: an outer lipid layer (secreted by the meibom...
Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...
Research Report on Changes in the Metabolome of Senescent Myoblasts Research Background As age increases, the function of skeletal muscle gradually deteriorates, a phenomenon closely related to the senescence of muscle stem cells (satellite cells). Satellite cells play a key role in muscle injury repair. However, during the aging process, the funct...
Sulforaphane Mimics Contractile Activity-Induced Mitochondrial Adaptations in Muscle Research Background Mitochondria are central regulators of skeletal muscle health, acting as the cell’s power plants. The function and quality of mitochondria directly impact muscle health. Exercise has been widely proven to be an effective means of enhancing mitoc...
USP35 Promotes Breast Cancer Progression by Regulating PFK-1 Ubiquitination to Mediate Glycolysis Academic Background Breast cancer is the most common malignant tumor affecting women worldwide and remains a leading cause of cancer-related mortality among women. Despite the development of various treatment strategies for different molecular subtypes...
New Discovery in the Mechanism of Radioresistance in Esophageal Squamous Cell Carcinoma: The Role of the RFC4 Gene Academic Background Esophageal squamous cell carcinoma (ESCC) is one of the most common gastrointestinal malignancies in China, and radiotherapy is a crucial treatment modality. However, radioresistance in tumor cells is a major cause ...
Mettl14 Promotes Ferroptosis in Vascular Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4 Academic Background Thoracic aortic aneurysm (TAA) is a severe vascular disease that often leads to aortic rupture and acute dissection, with extremely high mortality rates. Currently, the primary treatment for T...
Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...