Research Background The maintenance and repair of the hematopoietic system are crucial for the continuation of life and health in an organism. As the foundation of the hematopoietic system, the stability of hematopoietic stem cells (HSCs) is particularly important. The maintenance of the HSC pool relies on intrinsic and extrinsic factors, among whi...
Persistent Expression of Amphiregulin (AREG) in Intermediate Alveolar Stem Cells Drives Progressive Pulmonary Fibrosis Background Fibrotic diseases are a leading cause of up to 45% of deaths in developed countries. Pulmonary fibrosis is a disease characterized by alveolar structure damage and impaired gas exchange, with Idiopathic Pulmonary Fibrosi...
A Primate-Specific Endogenous Retroviral Envelope Protein Regulates Human Cardiomyocyte Development by Inhibiting SFRP2 Research Background and Significance Endogenous Retroviruses (ERVs) are remnants of ancient viral infections that integrated into the host genome and were inherited through the germline to modern human genomes during evolution. Th...
Multilayered Tissue Construction of a Micro-intestinal System Reproduces Mesenchymal Flow Research Background In recent years, constructing in vitro models of the human small intestine has made significant progress; however, fully replicating its complex structural and functional characteristics remains challenging. The goal of micro-intestinal tis...
Research Background and Objective As individuals age, hematopoietic stem cells (HSCs) progressively accumulate in the bone marrow, exhibiting metabolic resilience under various stress conditions. This metabolic resilience provides an aging advantage for HSCs, enabling them to maintain cell viability even under low metabolic conditions. Although agi...
The Role of Acetyl-CoA Metabolism in Maintaining the Synchronization of Human Trophoblast Stem Cells Research Background and Purpose The placenta is a crucial metabolic bridge between the mother and fetus during pregnancy, and its normal function is vital for the health of both. The placenta constantly differentiates through human trophoblast stem ...
Background and Problem In recent years, there has been significant progress in research on the multifaceted roles of mitochondria within cells. Aside from being the energy source of the cell, mitochondria also play crucial regulatory roles in processes such as cell proliferation, differentiation, and self-renewal, attracting widespread attention in...
Nynrin Protects Hematopoietic Stem Cell Function by Inhibiting Mitochondrial Permeability Transition Pore Opening Background and Research Motivation Hematopoietic stem cells (HSCs) are core cells that maintain the function of the hematopoietic system, showing unique adaptability to stress environments such as radiation damage. However, while conven...
Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...
The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...