Endothelial Cells Influence Insulin Sensitivity Through Metabolic Regulation of Resident Macrophages In recent years, metabolic diseases, especially insulin resistance and diabetes, have become significant global health issues. Muscle tissue, being one of the main organs for glucose metabolism in the human body, has its insulin sensitivity closely ...
Paper Report: The Role of MDH2 in Epitranscriptomic Metabolic Regulation of Glioblastoma Stem Cells Introduction and Background Glioblastoma (GBM) is the most common and lethal primary brain malignant tumor in adults. GBM cells utilize a metabolic pathway known as the Warburg effect, which involves increased glucose uptake through aerobic glycolysi...
Research Report on the Relationship Between High Protein Diet and Liver Fat Synthesis Background and Significance Globally, the prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is gradually increasing, becoming a common issue among people with obesity and insulin resistance. The pathological development of this disease...
Fructose Promotes Colorectal Cancer Growth by Modulating Tumor-Associated Macrophage Polarization Introduction In recent years, fructose intake has dramatically increased worldwide and is closely associated with obesity and metabolic syndrome, both of which are recognized risk factors for cancer development. Although previous studies have shown tha...
Background and Research Motivation Globally, Type 2 Diabetes (T2D) is a common metabolic disease characterized by the combined effects of genetic and environmental factors leading to dysfunction and/or cell death of pancreatic β-cells, resulting in insufficient insulin secretion. Based on findings from Genome-Wide Association Studies (GWAS), over 6...
The Role of Protein-Coupled Receptor GPR56 and Its Protective Mechanism in Ferroptosis-Induced Liver Injury In recent years, ferroptosis has emerged as a new form of programmed cell death, becoming a hot topic in scientific research. It is characterized by cell death due to phospholipid peroxidation and is significantly different from traditional a...
Influence of Dietary Timing on Circadian Rhythms of Gut Microbiota and Rheumatoid Arthritis Inflammation Background Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and progressive joint destruction, severely affecting the quality of life of patients. The inflammation and symptoms of RA p...
Background Introduction In the field of cellular energy metabolism research, mitochondrial calcium ion ([Ca²⁺]mt) is considered an important node in regulating mitochondrial oxidative function. Its role mainly involves activating calcium-sensitive dehydrogenases in the tricarboxylic acid cycle (TCA), including isocitrate dehydrogenase (IDH) and α-k...
Study on the Suppression of Deubiquitinase Rpn11 to Improve Non-Alcoholic Fatty Liver Disease (NAFLD) Background Introduction Non-alcoholic fatty liver disease (NAFLD) and its more severe form, non-alcoholic steatohepatitis (NASH), have become major global public health issues. The rapid increase in their incidence has made them leading causes of c...
Reversible Regulation of Retinal and Peripheral Nerve Function: Physiological Study of Serine and Glycine Background and Research Motivation Macular Telangiectasia Type 2 (Mactel) is an age-related retinal disease characterized by central vision loss. The molecular etiology of this disease is complex and is primarily associated with the metabolism ...