Application of Homologous Recombination Deficiency (HRD) in Tumor Patient Assessment and Treatment Planning Background Homologous Recombination (HR) is an important mechanism for repairing DNA Double-Strand Breaks (DSBs). However, when key genes in the HR repair pathway are mutated or epigenetically inactivated, cells are unable to effectively repa...
T2T-YAO: Assembly of a Han Chinese Full-length Diploid Reference Genome Scientific Background Since the launch of the Human Genome Project (HGP) thirty years ago, the field of biomedical research has set a long-term goal of constructing a complete and accurate human reference genome. However, due to limitations in sequencing technology, it has long...
Aging-induced trnaGlu-derived fragments disrupt glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Academic Background Mitochondrial cristae are inward protrusions of the inner mitochondrial membrane that undergo significant morphological changes during aging. However, the molecular mechanisms leading to th...
Background Introduction Metabolic dysfunction-associated fatty liver disease (MAFLD) is a globally prevalent chronic liver disease with an incidence rate of about 25%. Its prevalence is even higher among obese and type 2 diabetic populations. MAFLD is a complex systemic disease that can progress from metabolic-associated fatty liver (MAFL) to metab...
Background Introduction In modern society, metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD) is a common and serious chronic liver disease. However, the current understanding of its pathological mechanisms is not complete, including its progression to metabolic dysfunction-associated steatohepatitis (MASH), liver fi...
Role of GLP-1R in T Cells and Its Regulatory Mechanism for Anti-transplant Immunity and Anti-tumor Immunity Academic Background Glucagon-like peptide-1 receptor (GLP-1R) is known as a key regulator of glucose metabolism, primarily expressed in pancreatic β cells. Previous studies have clarified that GLP-1R agonists have significant effects in reduc...
Background Pancreatic Ductal Adenocarcinoma (PDAC) is a malignancy with a highly immunosuppressive tumor microenvironment (TME), showing strong resistance to immune checkpoint blockade (ICB) therapies, such as anti-PD-1 and anti-CTLA-4 treatments. Myeloid-Derived Suppressor Cells (MDSCs) derived from tumors play a critical role in tumor immune supp...
Inhibition of Acetyl-CoA Carboxylase Enhances Antitumor Immunity of Tumor-Infiltrating CD8+ T Cells Background and Objective In recent years, the impact of metabolic changes in the Tumor Microenvironment (TME) on the function of Tumor-Infiltrating Lymphocytes (TILs) has become a hot topic in immunological research. Although T cells possess strong a...
Background Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults, characterized by high recurrence and mortality rates. Despite active chemotherapy and radiotherapy post-surgery, GBM remains insensitive to existing treatment regimens, and patients usually have a poor prognosis. Recent studies indicate that the...
Background This paper aims to explore the function of somatic PKD1 mutations in cirrhosis and their impact on liver health without inducing cancer. The authors conducted this research because, although somatic mutations accumulate in non-malignant tissues and increase with age, it remains unclear whether these mutant clones are beneficial for organ...