Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...
GABAergic Synapses Between Auditory Efferent Neurons and Type II Spiral Ganglion Afferent Neurons in the Mouse Cochlea Background Introduction The complexity and precision of the auditory system have always been important topics in neuroscience research. As a key component of the auditory system, the interactions between cells and neurons within th...
The Impact of Circadian Rhythms and Behavioral Cycles on Caloric Intake in Adolescents Varies by Weight Status Academic Background The prevalence of obesity continues to rise globally, particularly among adolescents, increasing the risk of various chronic diseases such as type 2 diabetes, hypertension, and cardiovascular disorders. While previous s...
Brain Age Prediction Study Based on MEG Time Series Academic Background With the extension of human lifespan, understanding changes in the brain throughout the life cycle has become increasingly important. The structure and function of the brain undergo significant changes with age, which not only affect cognitive functions but are also closely rel...
KATP Channels Modulate Cortical Activity and Sleep by Regulating Glycolytic Flux Academic Background Glucose serves not only as the primary energy source for the brain but also as a biosynthetic substrate for neurotransmitter synthesis. Changes in glycolytic flux can alter neurotransmitter synthesis, thereby modulating cortical electroencephalograp...
Study on Hormone-Neuropeptide Pathway Inhibiting Sexual Receptivity in Immature Drosophila Females Academic Background Sexual maturation is a critical developmental event in the transition from juvenile to adult, accompanied by multiple physiological and behavioral changes. In Drosophila, the process of transition from an asexual state to sexual ma...
Robust Encoding of Stimulus-Response Mapping by Neurons in Visual Cortex Academic Background In the field of neuroscience, the visual cortex is considered a core area for processing visual information. The traditional view holds that neurons in the visual cortex primarily encode perceptual-related information, such as the location, shape, and color...
As the global aging problem intensifies, the incidence of neurodegenerative diseases (such as Alzheimer’s Disease, AD) is increasing year by year. Brain aging (Brain Aging, BA) is one of the significant risk factors for neurodegenerative diseases, but it does not completely align with chronological age (Chronological Age, CA). Traditional methods f...
The Detrimental Role of Arginase-1 in Macrophages After Ischemic Stroke Academic Background Ischemic stroke remains one of the leading causes of long-term disability worldwide. Although arginase-1 (Arg1) is typically associated with anti-inflammatory responses and tissue repair, its specific role in post-stroke recovery remains unclear. Arg1 is pre...
The Role of Notch, ERK, and SHH Signaling Pathways in the Fate Determination of Cortical Glial Cells and Olfactory Bulb Interneurons Academic Background During cortical development, neurogenesis and gliogenesis are two closely connected stages. Neurogenesis primarily generates neurons, while gliogenesis produces glial cells, including astrocytes an...