Pattern and Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma – A Case–Control Study Based on Liver Panoramic Digital Pathology

Study on the Pattern and Extent of Intrahepatic Infiltration in Perihilar Cholangiocarcinoma Academic Background Perihilar cholangiocarcinoma (PHCC) is one of the most common malignancies of the biliary system, and its treatment primarily relies on radical surgical resection. However, despite advancements in surgical techniques, the postoperative r...

Comparison of Long-Term Survival of Neoadjuvant Therapy Plus Surgery Versus Upfront Surgery and the Role of Adjuvant Therapy for T1b-2N0-1 Esophageal Cancer: A Population Study of the SEER Database and Chinese Cohort

Comparative Study on Treatment Strategies for Esophageal Cancer Academic Background Esophageal cancer is one of the digestive system tumors with high incidence and mortality rates worldwide, particularly in Asia, where the incidence of esophageal squamous cell carcinoma (SCC) is notably prominent. Although significant progress has been made in the ...

Global, Regional, and National Patterns of Change in the Burden of Nonmalignant Upper Gastrointestinal Diseases from 1990 to 2019 and the Forecast for the Next Decade

Trends and Future Predictions of the Global Burden of Non-Malignant Upper Gastrointestinal Diseases Academic Background Non-malignant upper gastrointestinal diseases, including Peptic Ulcer Disease (PUD), Gastritis and Duodenitis (GD), and Gastroesophageal Reflux Disease (GERD), pose significant challenges to global healthcare systems. These condit...

Ozaki Technique versus Ross Operation for Complex Aortic Valve Diseases in Children: A Retrospective Cohort Study

Comparison of Ozaki Technique and Ross Procedure in Children with Complex Aortic Valve Diseases Academic Background Aortic valve disease (AVD) in children is a complex and challenging condition, especially when surgical intervention is required. Traditional aortic valve replacement surgeries, such as mechanical or bioprosthetic valve replacements, ...

Hepatic Arterial Chemotherapy Infusion Combined with Tyrosine Kinase Inhibitors and PD-1 Inhibitors for Advanced Hepatocellular Carcinoma with High Risk: A Propensity Score Matching Study

Study on the Application of Hepatic Arterial Chemotherapy Combined with Targeted and Immunotherapy in Advanced Liver Cancer Background Liver cancer is the sixth most commonly diagnosed cancer globally and the third leading cause of cancer-related deaths. Most patients are diagnosed at an advanced stage, losing the opportunity for surgical resection...

Assessing the Global Burden of Mesothelioma: Trends, Socioeconomic Influences, and Asbestos Exposure – A Retrospective Cohort Study

Global Burden Assessment of Mesothelioma – Trends, Socioeconomic Influences, and Asbestos Exposure Academic Background Mesothelioma is a rare form of cancer that primarily affects the lining of the lungs (pleura) but can also occur in the lining of the abdominal cavity (peritoneum), heart, or testicles. Due to its rarity and long latency period, me...

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer: Insights from Quantitative Analysis and Retrospective Cohort Studies

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer Academic Background Prostate cancer is the second most common malignancy among men globally, particularly in its advanced stages, where it is often accompanied by metastases, significantly impacting patients’ quality of life and prognosis. Oligometastatic prost...

Hepatic Arterial Infusion Chemotherapy-Based Conversion Hepatectomy in Responders Versus Nonresponders with Hepatocellular Carcinoma: A Multicenter Cohort Study

Hepatic Arterial Infusion Chemotherapy (HAIC)-Based Conversion Hepatectomy in Patients with Hepatocellular Carcinoma Academic Background Hepatocellular carcinoma (HCC) is one of the most common liver malignancies worldwide, particularly in China, where its incidence and mortality rates remain high. Despite advancements in treatment strategies, radi...

Global, Regional, and National Burdens of Mild Traumatic Brain Injuries from 1990 to 2019: Findings from the Global Burden of Disease Study 2019 – A Cross-Sectional Study

Global Burden of Mild Traumatic Brain Injury: 1990-2019 Academic Background Mild traumatic brain injury (MTBI) is a common global health issue, particularly prevalent among the elderly population. MTBI not only causes symptoms such as headaches, dizziness, and fatigue but may also lead to long-term cognitive impairments, mood swings, and sleep diso...

Early-Life Malnutrition Exposure Associated with Higher Osteoporosis Risk in Adulthood: A Large-Scale Cross-Sectional Study

Early Malnutrition and the Risk of Osteoporosis in Adulthood: A Large-Scale Cross-Sectional Study Academic Background Osteoporosis is a chronic, systemic metabolic bone disease characterized by reduced bone density and deterioration of bone microstructure, leading to a significantly increased risk of fractures. Globally, approximately 9 million fra...