Neuropathologically Directed Profiling of PRNP Somatic and Germline Variants in Sporadic Human Prion Disease

Somatic and Germline PRNP Variants in Sporadic Human Prion Disease: A Neuropathological Study Introduction Prion diseases are a class of infectious, progressive, and fatal neurodegenerative diseases characterized by the pathological folding and aggregation of prion protein (PrP). Prion protein is encoded by the PRNP gene, with normal cellular prion...

Differences in the Cerebral Amyloid Angiopathy Proteome in Alzheimer's Disease and Mild Cognitive Impairment

Differences in the Cerebral Amyloid Angiopathy Proteome in Alzheimer's Disease and Mild Cognitive Impairment

Cerebral amyloid angiopathy (CAA) is a disease caused by the deposition of amyloid-beta (Aβ) in cerebral blood vessels. It is common not only in the elderly and almost all patients with Alzheimer’s disease (AD) but can also occur independently of other AD-related pathologies. The presence and severity of CAA promote the progression of AD-related cl...

Hands-On Neuroinformatics Education at the Crossroads of Online and In-Person: Lessons Learned from Neurohackademy

Neurohackademy: Combining Online and Offline Neurological Informatics Education Background Introduction In recent years, human neuroscience has entered an era of big data. Due to initiatives like the Human Connectome Project and the Adolescent Brain Cognitive Development (ABCD) study, scientists have acquired datasets of previously unimaginable sca...

Spin–Orbit Optical Broadband Achromatic Spatial Differentiation Imaging

Spin–Orbit Optical Broadband Achromatic Spatial Differentiation Imaging

Broadband Achromatic Spatial Differential Imaging with Optical Spin-Orbit Coupling Background Introduction In image processing, traditional spatial differentiation is typically accomplished through digital electronic computation. However, many big data applications require real-time and high-throughput image processing, which poses a tremendous cha...

Retrospective Study of Claudin 18 Isoform 2 Prevalence and Prognostic Association in Gastric and Gastroesophageal Junction Adenocarcinoma

Research Report on Claudin 18.2 in Gastric Cancer and Gastroesophageal Junction Adenocarcinoma Background Introduction Gastric cancer and gastroesophageal junction (G/GEJ) adenocarcinoma are major global health burdens. It is estimated that in 2020 alone, there were approximately 1.7 million new cases of gastric and esophageal cancers worldwide, wi...

Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma

Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma

Study on Real-world Outcomes of First-line Immune Checkpoint Inhibitor Therapy in Metastatic Melanoma Predicted by Tumor Mutational Burden The treatment of metastatic melanoma has significantly benefited from immune checkpoint inhibitors (ICIs) in recent years. However, despite the remarkable improvement in survival rates among melanoma patients, t...

Regorafenib in Patients with Solid Tumors: Results from the TAPUR Study

The Use of Regorafenib in Patients with BRAF-Mutant Solid Tumors: A Summary of Results from the TAPUR Study Background Introduction The BRAF gene belongs to the cytoplasmic serine/threonine kinase family and regulates cell proliferation and survival by activating the mitogen-activated protein kinase signaling pathway (MAPK). BRAF mutations can lead...

Tumor Size Is Not Everything: Advancing Radiomics as a Precision Medicine Biomarker in Oncology Drug Development and Clinical Care

In contemporary clinical oncology practice and drug development, the methods for evaluating tumor response are on the cusp of a revolution. Since the World Health Organization (WHO) proposed tumor response classification criteria for assessing the effectiveness of anti-cancer drugs in 1981, this field has undergone several improvements. Notably, th...

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen PET/CT: A Multicenter Retrospective Study

Transcriptomic Analysis of Prostate Cancer Patients: A Study on Nonlocalized Disease Based on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Academic Background Prostate cancer is a common male malignancy, and its diagnosis and treatment are crucial to patient prognosis. Transcriptomic analysis is a technique us...

Phase II Study of Erdafitinib in Tumors with FGFR Mutations or Fusions

Study on the Efficacy of Erdafitinib in Patients with Tumors with FGFR Mutations or Fusions This academic report is based on the scientific paper “Phase II Study of Erdafitinib in Patients with Tumors with Fibroblast Growth Factor Receptor Mutations or Fusions: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K2,” and introduces the...