Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

Academic Background With the intensification of global climate change, the impact of greenhouse gas (GHG) emissions on the environment and human health is becoming increasingly significant. The healthcare sector, as a major consumer of global energy and resources, contributes substantially to carbon emissions. Statistics show that the healthcare se...

Comparison of Tumor Burden Quantification between Liquid Biopsy and CT Academic Background In the era of precision medicine, the validation of non-invasive biomarkers faces numerous challenges. Tumor burden, as a potential prognostic marker, has been demonstrated to hold significant value in various studies. Tumor burden refers to the total amount ...

The Relationship Between Climate Change and Emergency Medical Imaging Utilization Academic Background Climate change and related environmental exposures have significantly impacted human health, leading to increased demand for healthcare services. High-temperature exposure and poor air quality are closely associated with increased emergency departm...

Association of Plasma GFAP and p-tau-181 with Synaptic Density in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and tau protein aggregates in the brain. Recent research has shown that multiple factors are involved in the dev...