Ultra-Fast PSMA-PET Staging in Prostate Cancer Enhanced by Artificial Intelligence

Application of AI-Enhanced Ultra-Fast PSMA-PET in Prostate Cancer Staging Academic Background Prostate cancer is one of the most common cancers among men globally, and accurate diagnosis and staging are crucial for treatment decision-making. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has become a standard examinati...

Early-phase Tau-PET as a proxy of brain metabolism in Alzheimer’s disease: a comparison with 18F-FDG-PET and early-phase Amyloid-PET

Early-phase 18F-Flortaucipir Tau-PET as a Proxy for Brain Metabolism in Alzheimer’s Disease Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by extracellular β-amyloid (Aβ) deposition, intracellular pathological tau protein accumulation, and neurodegeneration. These pathological changes begin accumulating in ...

Overexpression of REF-1 in Neovascular Eye Diseases and Its Inhibition by a Novel Compound

REF-1 Overexpression in Neovascular Eye Diseases and Therapeutic Targeting with a Novel Inhibitor Academic Background Neovascular age-related macular degeneration (nAMD) is a common blinding eye disease predominantly affecting individuals aged 60 years and older. nAMD is characterized by the formation of subretinal neovascularization, leading to re...

Anti-Angiogenic Therapy as Potential Treatment for Adenomyosis

Anti-Angiogenic Therapy as a Potential Treatment for Adenomyosis Academic Background Adenomyosis is a common gynecological condition characterized by endometrial tissue invading the myometrium, resulting in abnormal uterine bleeding, dysmenorrhea, and infertility. Despite its significant impact on women’s quality of life and public health, the etio...

Prediction of Monocular Defocus Curves in Pseudophakia with Different Pupil Sizes

Background With the widespread adoption of cataract surgery and lens replacement surgery, the optical performance of intraocular lenses (IOLs) has become increasingly critical in determining patients’ postoperative visual quality. Predicting clinical visual performance (such as visual acuity and defocus range) is an emerging area of interest in oph...

Three-Dimensional Monitoring of RBC Sedimentation in External Magnetic Fields

Study on Three-Dimensional Monitoring of Red Blood Cell Sedimentation under External Magnetic Fields: A Novel Scientific Perspective Background and Research Objective With the widespread use of electronic devices in modern society, humans are increasingly exposed to external magnetic fields (MFs) in their living environments. However, the potential...

Compact and Aberration Effects-Shielded Objective Intraocular Scatter Measurement System

Research Advances on a Novel Compact Double-Pass Intraocular Scatter Measurement System Academic Background According to the World Health Organization (WHO), cataracts are the leading cause of blindness globally, accounting for approximately 50% of all blindness cases. More than 20 million people worldwide suffer from vision loss or severe impairme...

Polarimetric Imaging of Peripheral Nerves: An Intraoperative Aid

Polarimetric Imaging Technology Assisting Intraoperative Peripheral Nerve Identification: A Cutting-Edge Study Peripheral nerves play a crucial role in the sensory and control networks of the human body, and their integrity and proper functioning are essential to our quality of life. Unfortunately, accidental peripheral nerve injuries are not uncom...

Challenging the Skin Pigmentation Bias in Tissue Oximetry via Time-Domain Near-Infrared Spectroscopy

Challenging Skin Pigmentation Bias: Application of Time-Domain Near-Infrared Spectroscopy in Tissue Oximetry Background and Motivation In recent years, optical technologies have been increasingly utilized in medical diagnostics and therapies. However, varying levels of skin pigmentation (which depend on melanin concentration in the skin) can signif...

Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels

Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels: A New Hope for Future Ophthalmic Biocompatible Implants In today’s era of advanced biotechnology and rapid developments in the biomedical field, refractive correction techniques have become a global research hotspot in ophthalmology. However, current corre...