The Relationship Between Mask Effectiveness and Population Coverage Rates Background and Research Motivation During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, mask-wearing, and test-trace-isolate strategies were widely applied to control the spread of the virus. Despite a large body of empirical resear...

Breakthrough in Automated Echocardiogram Diagnosis via Deep Learning: A Comparative Study of Self-Supervised Learning Methods Research Background With the rapid development of artificial intelligence and machine learning technologies, their role in medical imaging diagnosis is becoming increasingly significant. In particular, Self-Supervised Learni...

How to Reduce the Expectations and Demand for Antibiotics in the Face of the Threat of a “Post-Antibiotic Era” Introduction Antibiotic resistance is becoming a global public health threat. Although the evolution of this resistance is a biological process, human behavior, especially unnecessary antibiotic use in agricultural production and human med...

Research on a Unified Metagenomic Method for Rapid Detection of Microorganisms in Clinical Samples Background Introduction The background of this research is based on the current limitations of clinical metagenomics. Clinical metagenomics involves genome sequencing of all microorganisms in clinical samples, ideally performed after depleting human D...

Mapping Multimorbidity Progression Among 190 Diseases Background Globally, with the aging population and the significant increase in the negative impacts of chronic diseases, multimorbidity, the coexistence of multiple long-term conditions, has become an increasingly severe health challenge. Understanding the accumulation process of multimorbidity ...

In the global context, the prevalence of obesity is on the rise, bringing significant impacts to public health. Obesity is independently associated with the incidence and mortality of cardiovascular diseases, with an estimated economic burden exceeding $200 billion annually for healthcare systems. In recent years, glucagon-like peptide-1 (GLP-1) re...

The Mediating Role of Systemic Inflammation in the Differences in Cognitive Disease Incidence and the Moderating Role of Racialization This study examines the link between systemic racism and the increased burden of cognitive disease. Researchers investigated the mediating role of C-reactive protein (CRP) as a marker of systemic inflammation in the...

Needs Assessment for Establishing a Platform Trial Network: A Case Study on Metabolic Dysfunction-Associated Steatohepatitis (MASH) Academic Background The public health issue posed by Metabolic Dysfunction-Associated Steatohepatitis (MASH) is becoming increasingly severe. MASH is a condition caused by fat accumulation, inflammation, and cell damag...

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...

Research Background This study focuses on late-onset hypogonadism (LOH), aiming to uncover the mechanisms associated with age-related testicular function deviations, such as LOH, which are not yet fully understood. Utilizing single-cell RNA sequencing technology, the study analyzed the testicles of humans with LOH to identify supporting cells (SCs)...