SIRT1-RAB7 Axis Attenuates NLRP3 and STING Activation through Late Endosomal-Dependent Mitophagy during Sepsis-Induced Acute Lung Injury

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
acute lung injury   mitophagy   sepsis   SIRT1  

The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...

mRNA-LNP Prime Boost Evolves Precursors Toward VRC01-Like Broadly Neutralizing Antibodies in Preclinical Humanized Mouse Models

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology, Microbiology,
mRNA vaccines   broadly neutralizing antibodies   preclinical humanized mouse models   HIV   immunology   lipid nanoparticles  

Inducing and Optimizing VRC01-like Broadly Neutralizing Antibodies in Mouse Models with mRNA-LNP Background Introduction In recent years, the importance of acquiring broadly neutralizing antibodies (bnAbs) has been increasingly recognized in vaccine development, particularly in the field of HIV (Human Immunodeficiency Virus) vaccine research. The H...

Dendritic-Cell-Targeting Virus-Like Particles as Potent mRNA Vaccine Carriers

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
dendritic cells   virus-like particles   mRNA vaccine   SARS-CoV-2   high efficacy  

Dendritic-cell-targeting Virus-like Particles as Potent mRNA Vaccine Carriers Introduction In vaccine development, especially mRNA vaccines, significant achievements have been made in recent years. The mRNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19 have set a successful precedent, greatly advancing the development of mRNA v...