Interaction and Attenuation of Tumor-Specific CD8+ T Cell Responses by LRIG1 and VISTA Academic Background In recent years, the importance of immune checkpoint inhibitors (ICIs) such as Programmed Cell Death Protein 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) has received increasing attention. These inhibitors significantly improve the s...
TREM2 Deficiency Reprograms Gut Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy Background Immune checkpoint inhibitors (CPIs), such as drugs that block programmed cell death protein-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), have been successfully used to activate anti...
The Tumor Lactate-SREBP2 Signaling Pathway Drives Tolerogenic Dendritic Cell Maturation and Promotes Cancer Progression In recent years, the critical role of dendritic cells (DCs) in antitumor immunity has been widely recognized. However, many cancers cause DC dysfunction through mechanisms that are not fully understood. In a newly published study ...
Research Progress in Cancer Immunology: Tumor-derived Antigen Signals Induce CD8+ T-cell Exhaustion Localized to the Tumor Site Research Background and Purpose In recent years, immunotherapy has shown great potential in cancer treatment. However, tracking the behavior of immune cells after receiving antigen signals remains a challenge. Within tumor...
A Study on the Effect of YEATS2 Gene Knockdown on Dopaminergic Synaptic Integrity and Epileptic-like Behavior in Drosophila Background Introduction Epilepsy is a common neurological disorder characterized by abnormal electrical activities in the brain. These abnormal activities can lead to seizures and other neurological symptoms. Familial adult my...
Study Reveals Molecular Mechanisms of Enhanced Cocaine Craving in Rats During Withdrawal Background Introduction The issue of relapse in drug abuse poses a significant challenge in addiction treatment. According to related research, relapse behaviors in drug addiction are often triggered by environmental cues associated with drug use. This phenomen...
Academic Report on “Contralateral Delay Activity and Alpha Lateralization Reflect Retinotopic and Screen-Centered Reference Frames in Visual Memory” Introduction The visual system is organized in a lateralized manner, with the left and right visual fields processed by the contralateral cerebral cortex. This organization applies not only to percepti...
Mesoscale Organization of Ventral and Dorsal Visual Pathways in Macaque Monkey Revealed by 7T fMRI In the journal Progress in Neurobiology, a research team from the Interdisciplinary Institute of Neuroscience and Technology and the Department of Neurosurgery at the Second Hospital in Zhejiang University published a paper titled “Mesoscale organizat...
New Findings in Alzheimer’s Disease Research: The Regulatory Role of Signal Peptide Peptidase-Like 2b in the β-Amyloid Cascade Alzheimer’s Disease (AD) is a complex neurodegenerative disorder characterized by the abnormal accumulation of β-amyloid peptides (Aβ) in brain tissue and the formation of intracellular neurofibrillary tangles. The abnormal...
Analyzing the Gene Expression Network in Developing Hippocampus from the Perspective of NEIL3 Deficiency Background The hippocampus, a crucial region of the brain, is well-regarded for its key roles in memory consolidation, information processing, and emotional regulation. In the field of neuroscience research, the gene regulatory mechanisms of the...