Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...
Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer Authors Ningning Niu, Qingshen Xu, Wang Zheng, …, Kurong Jiang, Fengshi Yu, Xue Xu Jing published an article titled “Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts He...
Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...
Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...
Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...
The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...
Research Report on the Analysis of Immunological Characteristics of Peripheral Blood in Cancer Patients Cancer is a major and pervasive health problem globally. Despite significant advances in cancer treatment in recent years, many challenges remain, including how to accurately predict patients’ responses to various treatments. Immunotherapy, parti...
Analysis of Intratumor Heterogeneity in Liver Cancer Using Pharmacogenomics: A Study Based on a Large-Scale Organoid Biobank Academic Background Primary liver cancer (PLC) is the third leading cause of cancer-related deaths worldwide, mainly comprising hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and a mixed form called co...
Leptomeningeal Glial Modulation of Ischemic Stroke Reperfusion to Avoid Futile Recanalization Background Ischemic Stroke is caused by the sudden blockage of cerebral arteries, leading to millions of disabilities and deaths globally each year. The current treatment for ischemic stroke primarily involves intravenous thrombolysis or mechanical thrombe...
Time-Efficient Ultrasound Localization Microscopy Based on Novel Radial Basis Function Two-Dimensional Interpolation Introduction Ultrasound technology is a major medical imaging technique widely used for visualizing subcutaneous structures such as organs, muscles, and arteries due to its safety, cost-effectiveness, and non-invasiveness. However, t...