I. Research Background and Purpose The subcommissural organ (SCO) is a glandular structure located at the entrance of the ventricular system, which is present in humans and other vertebrates, but its function has not been fully elucidated. Previous studies have suggested that the SCO may be involved in the regulation of neural development and the m...

This study utilized induced pluripotent stem cell (iPSC)-derived neurons to investigate the critical role of lysosome-related vesicles in axonal mRNA transport and mitochondrial homeostasis maintenance. By knocking out BORC subunits (borcs5 or borcs7) to block the entry of lysosome-related vesicles into axons, researchers found that this led to a s...

This study investigated the role of the transcription factor Meis2 in regulating the development and differentiation of γ-aminobutyric acid (GABA)ergic neurons during mouse embryonic development. Researchers comprehensively applied techniques such as CRISPR/Cas9 knockdown, single-cell RNA sequencing (scRNA-seq), and lineage tracing, and found that ...

This paper was published in the May 2024 issue of Nature Neuroscience, with authors from institutions including the University of Minnesota. The study aimed to address individual differences in brain functional networks by establishing an open-source “Mapping Individual Differences in Brain Networks” (MIDB) resource. Research Background: Although b...

In this research paper from the journal Neuro-Oncology, the researchers investigated the relationship between the residual tumor cells at the resection margin after surgical removal and the progression-free survival (PFS) and overall survival (OS) in patients with wildtype isocitrate dehydrogenase (IDH wildtype) glioblastoma (GBM). The authors are ...