Academic News Report Background The motor cortex has long been the focus of research on motor control, mainly studying its role in active motor execution. However, even in the absence of actual motor output, the motor cortex also activates during motor imagery. Previous behavioral and imaging studies have confirmed this phenomenon, but how the spec...
Predictive Autoantibody Signature for Multiple Sclerosis Academic Background and Research Significance Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease that primarily affects the white matter of the central nervous system (CNS). Previous studies have mostly suggested that T cells play a major role in the pathogenesis of MS. Howe...
Spatial Enrichment and Genomic Analysis Reveal Association between NOMO1 and Amyotrophic Lateral Sclerosis Introduction Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease in which motor neurons in the brain and spinal cord gradually degrade. Although the genetic susceptibility of sporadic ALS patients remains uncertain, TDP-4...
NMDA Receptor Autoantibodies Mainly Damage Extrasynaptic Components Background Information In recent years, neuroimmunology research has revealed various neurological and psychiatric diseases associated with autoantibodies. In these disorders, autoantibodies target various molecules, including receptor membrane proteins, causing abnormal neural sys...
Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...
KATP Channel Mutation Disrupts Hippocampal Network Activity and Nocturnal Gamma Wave Changes Research Background ATP-sensitive potassium (KATP) channels are crucial ion channels that link cellular metabolism with electrical activity. Studies have shown that high activity of KATP channels is closely related to a rare disease—Developmental delay, Epi...
Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...
In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...
This is a large-scale prospective cohort study on depression in patients with Parkinson’s disease (PD). Researchers have used the vast cohort data from the UK Biobank to investigate the temporal association between depression and the onset of PD, the relationship between depression and brain region structure in PD patients, and the impact of depres...
This paper reports on research investigating how zebra finches recover their complex learned behaviors following large-scale neuronal perturbations. The researchers selectively disrupted the activity of the projection neurons in the HVC (hyperpallium ventralis) region critical for song sequence generation in zebra finches using genetic tools, leadi...