Study on the Safety and Efficacy of Algorithmically Controlled Electroporation for Treating Spontaneous Equine Melanomas In recent years, electroporation, specifically irreversible electroporation (IRE), has shown significant potential as a non-thermal ablation technique in tumor treatment. Compared to traditional thermal ablation methods, IRE can ...

Piezo1 and Piezo2 Mechanosensitive Ion Channels Regulate the Response of Rodents to Transcranial Focused Ultrasound Stimulation of the Motor Cortex Academic Background Transcranial Focused Ultrasound (TFUS) neuromodulation is a non-invasive, deep brain stimulation technique that shows great potential in the study of neural circuits and the treatmen...

Prediction of Ventricular Fibrillation in Myocardial Infarction Model in Pigs Based on T-peak-to-T-end Interval Variation Using Time Warping Technique Background Introduction Source of the Paper Sudden Cardiac Death (SCD) is a leading cause of mortality worldwide, with one of its primary pathogenic mechanisms being Ventricular Fibrillation (VF), es...

Academic News Report: New MRI Technology Achieves Biological Fluorescence Imaging by Detecting Local Hemodynamics of Photosensitive Blood Vessels Academic Background Introduction Bioluminescent probes are widely used for monitoring biomedical processes and cellular targets in living animals. However, the absorption and scattering of visible light b...

Spatial Multi-omics High Throughput In Situ Pairwise Sequencing at Subcellular Resolution Research Background and Objectives With the continuous advancement in biomedical research, the application of multi-omics technologies in understanding cell functions and disease mechanisms has gained increasing attention. However, many current in situ sequenc...

Clinical and Pathological Heterogeneity of Alzheimer’s Disease and Patterns of Glial Cell Activation Academic Background Alzheimer’s Disease (AD), as the primary cause of dementia in the elderly, has always been a hot topic in research due to its pathological heterogeneity. Previous studies have indicated that the clinical symptoms of AD are divers...

Precise Colorectal Cancer Screening Based on Customized Intervals Using Fecal Hemoglobin Concentration Researchers: Amy Ming-Fang Yen, Yang-Ching Chen, Yu-Lin Ding, Wen-Zhu Qiu, Han-Mo Qiu, Tony Hsiu-Hsi Chen, Sam Li-Sheng Chen Academic Background Colorectal cancer (CRC) is the third most prevalent malignancy worldwide. In recent years, significant...

Oncolytic Mineralized Bacteria May Be Used for Tumor Immunotherapy via Local Injection Research Background As a novel cancer treatment method, bacteria-based cancer immunotherapy has a long history dating back to the late 19th century when heated, inactivated bacteria were used to treat sarcomas. Initial trials found that these bacteria could trigg...

Generation of Synthetic Whole-Slide Images of Tumors from RNA Sequencing Data via Cascaded Diffusion Models A recent study published in Nature Biomedical Engineering, titled “Generation of Synthetic Whole-Slide Image Tiles of Tumours from RNA-Sequencing Data via Cascaded Diffusion Models,” has garnered significant attention. This research, conducte...

Utilization of Lipid Nanoparticles-mRNA Formulations to Eliminate ROS and Accelerate Diabetic Wound Healing Diabetic wounds are common complications in patients with hyperglycemia, characterized by high incidence and recurrence rates, causing substantial global economic losses. Existing treatments, including wound offloading and growth factor thera...