Exploring the Crucial Role of the Motor Cortex in Basal Ganglia and Dynamic Motor Control Research Background and Motivation The role of the motor cortex (Motor Cortex, M1) in motor generation and regulation has long been a significant topic in neuroscience. The interaction between M1 and the striatum in selecting and executing goal-directed action...

Scientific News Report: The Molecular and Neural Circuit Mechanisms in the Globus Pallidus for Controlling Cocaine-Induced Behavioral Plasticity In the field of the neurobiology of drug abuse, this paper provides a new perspective for exploring cocaine-induced behavioral plasticity and neural circuit regulation. The research team centered on the Gl...

I. Research Background The taste of food has a significant impact on the feeding motivation of animals. Previous research has shown that taste, as a positive feedback signal, can enhance the feeding motivation of animals. However, in recent years, studies on whether taste also plays a role in suppressing feeding and helping achieve negative feedbac...

Research Background The neural transduction mechanisms of tactile vibration coding have been a hot topic in neuroscience research. In daily life, we acquire information about the external environment through the perception of vibrations, such as phone vibration alerts or car proximity warnings. In mammals, high-frequency vibration perception is mai...

With the advancement of neuroscience research, the crucial role of N-methyl-D-aspartate receptors (NMDA receptors, NMDAR) in neurotransmission and cognitive functions has become increasingly clear. NMDARs are a type of ionotropic glutamate receptor that play an important role in neuronal synapses, responsible for rapid excitatory transmission and s...

Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...

Study on the Effect of Glucose Regulation on Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Patients with Fatty Liver Disease Research Background and Significance Metabolic-dysfunction-associated Steatotic Liver Disease (MASLD) has become one of the major challenges in global health in the 21st century. This condition is often acc...

The Role of Protein-Coupled Receptor GPR56 and Its Protective Mechanism in Ferroptosis-Induced Liver Injury In recent years, ferroptosis has emerged as a new form of programmed cell death, becoming a hot topic in scientific research. It is characterized by cell death due to phospholipid peroxidation and is significantly different from traditional a...

Influence of Dietary Timing on Circadian Rhythms of Gut Microbiota and Rheumatoid Arthritis Inflammation Background Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and progressive joint destruction, severely affecting the quality of life of patients. The inflammation and symptoms of RA p...

Fusobacterium nucleatum Promotes Anti-PD-1 Therapy in Microsatellite-Stable Colorectal Cancer Background Introduction With the rise of immune checkpoint blockade (ICB) therapy, a new dawn has emerged in cancer treatment. However, despite the approval of PD-1 targeting drugs (e.g., Pembrolizumab) for certain types of colorectal cancer (CRC) patients...